Impact of post-hatching maturation on the pharmacokinetics of paracetamol in zebrafish larvae

Zebrafish larvae are increasingly used in pharmacological and toxicological studies, but it is often overlooked that internal exposure to exogenous compounds, rather than the incubation medium concentration, is driving observed effects. Moreover, as the zebrafish larva is a developing organism, cont...

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Detalles Bibliográficos
Autores principales: van Wijk, Rob C., Krekels, Elke H. J., Kantae, Vasudev, Harms, Amy C., Hankemeier, Thomas, van der Graaf, Piet H., Spaink, Herman P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377609/
https://www.ncbi.nlm.nih.gov/pubmed/30770889
http://dx.doi.org/10.1038/s41598-019-38530-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377609/
https://www.ncbi.nlm.nih.gov/pubmed/30770889
http://dx.doi.org/10.1038/s41598-019-38530-w

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