Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction

Androgen receptor (AR) is regulated by SUMOylation at its transactivation domain. In vitro, the SUMOylation is linked to transcriptional repression and/or target gene-selective regulation. Here, we generated a mouse model (ArKI) in which the conserved SUMO acceptor lysines of AR are permanently abol...

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Detalles Bibliográficos
Autores principales: Zhang, Fu-Ping, Malinen, Marjo, Mehmood, Arfa, Lehtiniemi, Tiina, Jääskeläinen, Tiina, Niskanen, Einari A., Korhonen, Hanna, Laiho, Asta, Elo, Laura L., Ohlsson, Claes, Kotaja, Noora, Poutanen, Matti, Sipilä, Petra, Palvimo, Jorma J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377611/
https://www.ncbi.nlm.nih.gov/pubmed/30770815
http://dx.doi.org/10.1038/s41467-019-08730-z

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