A functional subset of CD8(+) T cells during chronic exhaustion is defined by SIRPα expression

Prolonged exposure of CD8(+) T cells to antigenic stimulation, as in chronic viral infections, leads to a state of diminished function termed exhaustion. We now demonstrate that even during exhaustion there is a subset of functional CD8(+) T cells defined by surface expression of SIRPα, a protein no...

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Detalles Bibliográficos
Autores principales: Myers, Lara M., Tal, Michal Caspi, Torrez Dulgeroff, Laughing Bear, Carmody, Aaron B., Messer, Ronald J., Gulati, Gunsagar, Yiu, Ying Ying, Staron, Matthew M., Angel, Cesar Lopez, Sinha, Rahul, Markovic, Maxim, Pham, Edward A., Fram, Benjamin, Ahmed, Aijaz, Newman, Aaron M., Glenn, Jeffrey S., Davis, Mark M., Kaech, Susan M., Weissman, Irving L., Hasenkrug, Kim J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377614/
https://www.ncbi.nlm.nih.gov/pubmed/30770827
http://dx.doi.org/10.1038/s41467-019-08637-9

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