MPC1 deficiency accelerates lung adenocarcinoma progression through the STAT3 pathway

Mitochondrial pyruvate carrier 1 (MPC1), a key factor that controls pyruvate transportation in the mitochondria, is known to be frequently dysregulated in tumor initiation and progression. However, the clinical relevance and potential molecular mechanisms of MPC1 in lung adenocarcinoma (LAC) progres...

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Detalles Bibliográficos
Autores principales: Zou, Hongbo, Chen, Qian, Zhang, Anmei, Wang, Songtao, Wu, Hong, Yuan, Ye, Wang, Shuang, Yu, Jing, Luo, Mao, Wen, Xianmei, Cui, Wei, Fu, Wenjuan, Yu, Ruilian, Chen, Lin, Zhang, Ming, Lan, Haitao, Zhang, Xia, Xie, Qichao, Jin, Guoxiang, Xu, Chuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377639/
https://www.ncbi.nlm.nih.gov/pubmed/30770798
http://dx.doi.org/10.1038/s41419-019-1324-8

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