Soft fibrin matrix downregulates DAB2IP to promote Nanog-dependent growth of colon tumor-repopulating cells

Colon cancer stem cells (CSCs) have been shown to be responsible for the recurrence and metastasis of colorectal cancer (CRC). As a crucial microenvironmental factor, extracellular matrix (ECM) stiffness is known to affect the stemness of CSCs. Recently, fibrin deposition in the stroma of CRC was de...

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Detalles Bibliográficos
Autores principales: Zhang, Meng, Xu, Cong, Wang, Hai-zhou, Peng, Ya-nan, Li, Hai-ou, Zhou, Yun-jiao, Liu, Shi, Wang, Fan, Liu, Lan, Chang, Ying, Zhao, Qiu, Liu, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377646/
https://www.ncbi.nlm.nih.gov/pubmed/30770783
http://dx.doi.org/10.1038/s41419-019-1309-7

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