Cargando…

The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes

Short-chain fatty acids (SCFAs) have immunomodulatory effects, but the underlying mechanisms are not well understood. Here we show that pentanoate, a physiologically abundant SCFA, is a potent regulator of immunometabolism. Pentanoate induces IL-10 production in lymphocytes by reprogramming their me...

Descripción completa

Detalles Bibliográficos
Autores principales:	Luu, Maik, Pautz, Sabine, Kohl, Vanessa, Singh, Rajeev, Romero, Rossana, Lucas, Sébastien, Hofmann, Jörg, Raifer, Hartmann, Vachharajani, Niyati, Carrascosa, Lucia Campos, Lamp, Boris, Nist, Andrea, Stiewe, Thorsten, Shaul, Yoav, Adhikary, Till, Zaiss, Mario M., Lauth, Matthias, Steinhoff, Ulrich, Visekruna, Alexander
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377655/ https://www.ncbi.nlm.nih.gov/pubmed/30770822 http://dx.doi.org/10.1038/s41467-019-08711-2

Ejemplares similares

Transcription factor c-Rel is indispensable for generation of thymic but not of peripheral Foxp3(+) regulatory T cells
por: Luu, Maik, et al.
Publicado: (2017)

Prevention of colitis-associated cancer by selective targeting of immunoproteasome subunit LMP7
por: Vachharajani, Niyati, et al.
Publicado: (2017)

The Microbial Metabolite Butyrate Induces Expression of Th1-Associated Factors in CD4(+) T Cells
por: Kespohl, Meike, et al.
Publicado: (2017)

Regulation of the effector function of CD8(+) T cells by gut microbiota-derived metabolite butyrate
por: Luu, Maik, et al.
Publicado: (2018)

Functional heterogeneity of gut-resident regulatory T cells
por: Luu, Maik, et al.
Publicado: (2017)

The Impact of Gut Microbiota-Derived Metabolites on the Tumor Immune Microenvironment
por: Luu, Maik, et al.
Publicado: (2023)

Tumor-suppressive disruption of cancer subtype-associated super enhancer circuits by small molecule treatment
por: Koeniger, Anke, et al.
Publicado: (2023)

Anhydrous polymeric zinc(II) pentanoate
por: Taylor, Richard A., et al.
Publicado: (2008)

4-Hydroxy-3-nitrophenyl pentanoate
por: Yang, Hongxiang
Publicado: (2010)

The Role of Short-Chain Fatty Acids and Bile Acids in Intestinal and Liver Function, Inflammation, and Carcinogenesis
por: Visekruna, Alexander, et al.
Publicado: (2021)

Targeting metabolic rewiring might decrease spread of tumor cells: Mitochondrial tRNA modifications promote cancer metastasis
por: Luu, Maik, et al.
Publicado: (2022)

Activation of Cilia-Independent Hedgehog/GLI1 Signaling as a Novel Concept for Neuroblastoma Therapy
por: Koeniger, Anke, et al.
Publicado: (2021)

Microbial short-chain fatty acids modulate CD8(+) T cell responses and improve adoptive immunotherapy for cancer
por: Luu, Maik, et al.
Publicado: (2021)

Exploring the Molecular Mechanisms Underlying the Protective Effects of Microbial SCFAs on Intestinal Tolerance and Food Allergy
por: Luu, Maik, et al.
Publicado: (2020)

4-Methyl-2-(2-nitrobenzenesulfonamido)pentanoic acid
por: Arshad, Muhammad Nadeem, et al.
Publicado: (2012)

Chromatin Binding of c-REL and p65 Is Not Limiting for Macrophage IL12B Transcription During Immediate Suppression by Ovarian Carcinoma Ascites
por: Unger, Annika, et al.
Publicado: (2018)

Selected commensals educate the intestinal vascular and immune system for immunocompetence
por: Romero, Rossana, et al.
Publicado: (2022)

Synthesis of 5-(6-hydroxy-7H-purine-8-ylthio)- 2-(N-hydroxyformamido)pentanoic acid
por: Zhang, Yanmei, et al.
Publicado: (2010)

(E)-4-[2-(2-Hydroxybenzoyl)hydrazinylidene]pentanoic acid
por: Qiao, Yanling, et al.
Publicado: (2011)

Dendrobaena veneta avoids ethyl pentanoate and ethyl hexanoate, two compounds produced by the soil fungus Geotrichum candidum
por: Reed, Eileen M.S., et al.
Publicado: (2021)

SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells
por: Sachs, Parysatis, et al.
Publicado: (2019)

Drosophila melanogaster tPlus3a and tPlus3b ensure full male fertility by regulating transcription of Y-chromosomal, seminal fluid, and heat shock genes
por: Hundertmark, Tim, et al.
Publicado: (2019)

IL-17 and TNF-α Are Key Mediators of Moraxella catarrhalis Triggered Exacerbation of Allergic Airway Inflammation
por: Alnahas, Safa, et al.
Publicado: (2017)

Construcción de la planta de isomerización de pentanos en el complejo petroquímico de La Cangrejera
por: Gracia Bezares, Abel
Publicado: (1997)

A Key Role for NF-κB Transcription Factor c-Rel in T-Lymphocyte-Differentiation and Effector Functions
por: Visekruna, Alexander, et al.
Publicado: (2012)

Dietary cellulose induces anti-inflammatory immunity and transcriptional programs via maturation of the intestinal microbiota
por: Fischer, Florence, et al.
Publicado: (2020)

Interferon signaling in ascites-associated macrophages is linked to a favorable clinical outcome in a subgroup of ovarian carcinoma patients
por: Adhikary, Till, et al.
Publicado: (2017)

Ush regulates hemocyte-specific gene expression, fatty acid metabolism and cell cycle progression and cooperates with dNuRD to orchestrate hematopoiesis
por: Lenz, Jonathan, et al.
Publicado: (2021)

Proteotranscriptomics Reveal Signaling Networks in the Ovarian Cancer Microenvironment
por: Worzfeld, Thomas, et al.
Publicado: (2018)

Ethyl 2-cyano-5-oxo-5-(thiophen-2-yl)-3-(3,4,5-trimethoxyphenyl)pentanoate
por: Prabhuswamy, M., et al.
Publicado: (2012)

MGA, L3MBTL2 and E2F6 determine genomic binding of the non-canonical Polycomb repressive complex PRC1.6
por: Stielow, Bastian, et al.
Publicado: (2018)

Distinct CoREST complexes act in a cell-type-specific manner
por: Mačinković, Igor, et al.
Publicado: (2019)

The Role of Immunoproteasomes in Tumor-Immune Cell Interactions in Melanoma and Colon Cancer
por: Leister, Hanna, et al.
Publicado: (2022)

Synthesis and Antibacterial Evaluation of (S,Z)-4-methyl-2-(4-oxo-5-((5-substituted phenylfuran-2-yl) methylene)-2-thioxothiazolidin-3-yl)Pentanoic Acids
por: Song, Ming-Xia, et al.
Publicado: (2015)

In Vivo and In Silico Analgesic Activity of Ficus populifolia Extract Containing 2-O-β-D-(3′,4′,6′-Tri-acetyl)-glucopyranosyl-3-methyl Pentanoic Acid
por: Mohammed, Hamdoon A., et al.
Publicado: (2023)

Draft genome sequence of Pseudomonas sp. ER28, a cyclohexane pentanoic acid degrader isolated from oil sands process-affected water from Alberta, Canada
por: Goff, Kira L., et al.
Publicado: (2023)

Cancer genome and tumor microenvironment: Reciprocal crosstalk shapes lung cancer plasticity
por: Mansouri, Siavash, et al.
Publicado: (2022)

Learning from the microbes: exploiting the microbiome to enforce T cell immunotherapy
por: Staudt, Sarah, et al.
Publicado: (2023)

Zinc Finger Independent Genome-Wide Binding of Sp2 Potentiates Recruitment of Histone-Fold Protein Nf-y Distinguishing It from Sp1 and Sp3
por: Völkel, Sara, et al.
Publicado: (2015)

Galectin-3 interacts with components of the nuclear ribonucleoprotein complex
por: Fritsch, Katharina, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_9af14v7c08u9rel8jkqgrgen1u