Stress-induced inactivation of the Staphylococcus aureus purine biosynthesis repressor leads to hypervirulence

Staphylococcus aureus is a significant cause of human infection. Here, we demonstrate that mutations in the transcriptional repressor of purine biosynthesis, purR, enhance the pathogenic potential of S. aureus. Indeed, systemic infection with purR mutants causes accelerated mortality in mice, which...

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Detalles Bibliográficos
Autores principales: Goncheva, Mariya I., Flannagan, Ronald S., Sterling, Brigid E., Laakso, Holly A., Friedrich, Nancy C., Kaiser, Julienne C., Watson, David W., Wilson, Christy H., Sheldon, Jessica R., McGavin, Martin J., Kiser, Patti K., Heinrichs, David E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377658/
https://www.ncbi.nlm.nih.gov/pubmed/30770821
http://dx.doi.org/10.1038/s41467-019-08724-x

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