Copy-choice recombination during mitochondrial L-strand synthesis causes DNA deletions

Mitochondrial DNA (mtDNA) deletions are associated with mitochondrial disease, and also accumulate during normal human ageing. The mechanisms underlying mtDNA deletions remain unknown although several models have been proposed. Here we use deep sequencing to characterize abundant mtDNA deletions in...

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Detalles Bibliográficos
Autores principales: Persson, Örjan, Muthukumar, Yazh, Basu, Swaraj, Jenninger, Louise, Uhler, Jay P., Berglund, Anna-Karin, McFarland, Robert, Taylor, Robert W., Gustafsson, Claes M., Larsson, Erik, Falkenberg, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377680/
https://www.ncbi.nlm.nih.gov/pubmed/30770810
http://dx.doi.org/10.1038/s41467-019-08673-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377680/
https://www.ncbi.nlm.nih.gov/pubmed/30770810
http://dx.doi.org/10.1038/s41467-019-08673-5

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