Cargando…
LXRα promotes cell metastasis by regulating the NLRP3 inflammasome in renal cell carcinoma
Notwithstanding the researches on biomarkers and targeted therapies in renal cell carcinomas (RCC) have made progress in the last decades, the application of the biomarkers and targeted therapy agents for RCC in clinic are restricted because of their limitation or side effects. Liver X receptors (LX...
Autores principales: | , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377709/ https://www.ncbi.nlm.nih.gov/pubmed/30770793 http://dx.doi.org/10.1038/s41419-019-1345-3 |
_version_ | 1783395796963557376 |
---|---|
author | Wang, KeShan Xu, TianBo Ruan, HaiLong Xiao, HaiBing Liu, Jingchong Song, ZhengShuai Cao, Qi Bao, Lin Liu, Di Wang, Cheng Cheng, Gong Liang, HuaGeng Chen, ZhaoHui Yang, HongMei Chen, Ke Zhang, XiaoPing |
author_facet | Wang, KeShan Xu, TianBo Ruan, HaiLong Xiao, HaiBing Liu, Jingchong Song, ZhengShuai Cao, Qi Bao, Lin Liu, Di Wang, Cheng Cheng, Gong Liang, HuaGeng Chen, ZhaoHui Yang, HongMei Chen, Ke Zhang, XiaoPing |
author_sort | Wang, KeShan |
collection | PubMed |
description | Notwithstanding the researches on biomarkers and targeted therapies in renal cell carcinomas (RCC) have made progress in the last decades, the application of the biomarkers and targeted therapy agents for RCC in clinic are restricted because of their limitation or side effects. Liver X receptors (LXRs) and the NLRP3 inflammasome have been the research hotspots in recent years. In our study, we integrated bioinformatics analysis, molecular biology experiments and biological function experiments to study the roles of LXRα and the NLRP3 inflammasome in RCC. The study demonstrated that the elevated LXRα expression is correlated with a poor prognosis in RCC. Furthermore, our study revealed the expression levels and roles of the NLRP3 inflammasome in RCC for the first time. This research demonstrated that LXRα could promote the metastasis of RCC cells by suppressing the expression of the NLRP3 inflammasome. In Brief, LXRα had the possibility to be a novel diagnostic and prognostic biomarker and therapeutic target in renal cell cancer and LXRα could regulate the metastasis of renal cell cancer via NLRP3 inflammamsome. |
format | Online Article Text |
id | pubmed-6377709 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-63777092019-02-19 LXRα promotes cell metastasis by regulating the NLRP3 inflammasome in renal cell carcinoma Wang, KeShan Xu, TianBo Ruan, HaiLong Xiao, HaiBing Liu, Jingchong Song, ZhengShuai Cao, Qi Bao, Lin Liu, Di Wang, Cheng Cheng, Gong Liang, HuaGeng Chen, ZhaoHui Yang, HongMei Chen, Ke Zhang, XiaoPing Cell Death Dis Article Notwithstanding the researches on biomarkers and targeted therapies in renal cell carcinomas (RCC) have made progress in the last decades, the application of the biomarkers and targeted therapy agents for RCC in clinic are restricted because of their limitation or side effects. Liver X receptors (LXRs) and the NLRP3 inflammasome have been the research hotspots in recent years. In our study, we integrated bioinformatics analysis, molecular biology experiments and biological function experiments to study the roles of LXRα and the NLRP3 inflammasome in RCC. The study demonstrated that the elevated LXRα expression is correlated with a poor prognosis in RCC. Furthermore, our study revealed the expression levels and roles of the NLRP3 inflammasome in RCC for the first time. This research demonstrated that LXRα could promote the metastasis of RCC cells by suppressing the expression of the NLRP3 inflammasome. In Brief, LXRα had the possibility to be a novel diagnostic and prognostic biomarker and therapeutic target in renal cell cancer and LXRα could regulate the metastasis of renal cell cancer via NLRP3 inflammamsome. Nature Publishing Group UK 2019-02-15 /pmc/articles/PMC6377709/ /pubmed/30770793 http://dx.doi.org/10.1038/s41419-019-1345-3 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Wang, KeShan Xu, TianBo Ruan, HaiLong Xiao, HaiBing Liu, Jingchong Song, ZhengShuai Cao, Qi Bao, Lin Liu, Di Wang, Cheng Cheng, Gong Liang, HuaGeng Chen, ZhaoHui Yang, HongMei Chen, Ke Zhang, XiaoPing LXRα promotes cell metastasis by regulating the NLRP3 inflammasome in renal cell carcinoma |
title | LXRα promotes cell metastasis by regulating the NLRP3 inflammasome in renal cell carcinoma |
title_full | LXRα promotes cell metastasis by regulating the NLRP3 inflammasome in renal cell carcinoma |
title_fullStr | LXRα promotes cell metastasis by regulating the NLRP3 inflammasome in renal cell carcinoma |
title_full_unstemmed | LXRα promotes cell metastasis by regulating the NLRP3 inflammasome in renal cell carcinoma |
title_short | LXRα promotes cell metastasis by regulating the NLRP3 inflammasome in renal cell carcinoma |
title_sort | lxrα promotes cell metastasis by regulating the nlrp3 inflammasome in renal cell carcinoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377709/ https://www.ncbi.nlm.nih.gov/pubmed/30770793 http://dx.doi.org/10.1038/s41419-019-1345-3 |
work_keys_str_mv | AT wangkeshan lxrapromotescellmetastasisbyregulatingthenlrp3inflammasomeinrenalcellcarcinoma AT xutianbo lxrapromotescellmetastasisbyregulatingthenlrp3inflammasomeinrenalcellcarcinoma AT ruanhailong lxrapromotescellmetastasisbyregulatingthenlrp3inflammasomeinrenalcellcarcinoma AT xiaohaibing lxrapromotescellmetastasisbyregulatingthenlrp3inflammasomeinrenalcellcarcinoma AT liujingchong lxrapromotescellmetastasisbyregulatingthenlrp3inflammasomeinrenalcellcarcinoma AT songzhengshuai lxrapromotescellmetastasisbyregulatingthenlrp3inflammasomeinrenalcellcarcinoma AT caoqi lxrapromotescellmetastasisbyregulatingthenlrp3inflammasomeinrenalcellcarcinoma AT baolin lxrapromotescellmetastasisbyregulatingthenlrp3inflammasomeinrenalcellcarcinoma AT liudi lxrapromotescellmetastasisbyregulatingthenlrp3inflammasomeinrenalcellcarcinoma AT wangcheng lxrapromotescellmetastasisbyregulatingthenlrp3inflammasomeinrenalcellcarcinoma AT chenggong lxrapromotescellmetastasisbyregulatingthenlrp3inflammasomeinrenalcellcarcinoma AT lianghuageng lxrapromotescellmetastasisbyregulatingthenlrp3inflammasomeinrenalcellcarcinoma AT chenzhaohui lxrapromotescellmetastasisbyregulatingthenlrp3inflammasomeinrenalcellcarcinoma AT yanghongmei lxrapromotescellmetastasisbyregulatingthenlrp3inflammasomeinrenalcellcarcinoma AT chenke lxrapromotescellmetastasisbyregulatingthenlrp3inflammasomeinrenalcellcarcinoma AT zhangxiaoping lxrapromotescellmetastasisbyregulatingthenlrp3inflammasomeinrenalcellcarcinoma |