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Gigaxonin E3 ligase governs ATG16L1 turnover to control autophagosome production
Autophagy is an essential self-digestion machinery for cell survival and homoeostasis. Membrane elongation is fundamental, as it drives the formation of the double-membrane vesicles that engulf cytosolic material. LC3-lipidation, the signature of autophagosome formation, results from a complex ubiqu...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377711/ https://www.ncbi.nlm.nih.gov/pubmed/30770803 http://dx.doi.org/10.1038/s41467-019-08331-w |