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Simultaneous Quantification of Methotrexate and Its Metabolite 7-Hydroxy-Methotrexate in Human Plasma for Therapeutic Drug Monitoring

OBJECTIVE: To establish and validate a simple, sensitive, and rapid liquid chromatography tandem mass spectrometry (LC-MS/MS) method for the determination of methotrexate (MTX) and its major metabolite 7-hydroxy-methotrexate (7-OH-MTX) in human plasma. METHOD: The chromatographic separation was achi...

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Detalles Bibliográficos
Autores principales:	Ren, Xinxin, Wang, Zhipeng, Yun, Yunlei, Meng, Guangyi, Zhang, Xialan, Ding, Huamin, Xu, Ying, Bai, Hansheng, Liu, Jing, Li, Xia, Gao, Shouhong, Huang, Lifeng, Chen, Wansheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378003/ https://www.ncbi.nlm.nih.gov/pubmed/30853983 http://dx.doi.org/10.1155/2019/1536532

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