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Metabolite Markers for Characterizing Sasang Constitution Type through GC-MS and (1)H NMR-Based Metabolomics Study

Sasang constitutional medicine classifies human beings into four types based on their physical and psychological characteristics. Despite its potential value in achieving personalized medicine, the diagnosis of sasang constitution (SC) type is complex and subjective. In this study, gas chromatograph...

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Autores principales: Kim, Eun-Ju, Hong, Young-Shick, Seo, Seung-Ho, Park, Seong-Eun, Na, Chang-Su, Son, Hong-Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378031/
https://www.ncbi.nlm.nih.gov/pubmed/30854017
http://dx.doi.org/10.1155/2019/8783496
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author Kim, Eun-Ju
Hong, Young-Shick
Seo, Seung-Ho
Park, Seong-Eun
Na, Chang-Su
Son, Hong-Seok
author_facet Kim, Eun-Ju
Hong, Young-Shick
Seo, Seung-Ho
Park, Seong-Eun
Na, Chang-Su
Son, Hong-Seok
author_sort Kim, Eun-Ju
collection PubMed
description Sasang constitutional medicine classifies human beings into four types based on their physical and psychological characteristics. Despite its potential value in achieving personalized medicine, the diagnosis of sasang constitution (SC) type is complex and subjective. In this study, gas chromatography–mass spectrometry and (1)H nuclear magnetic resonance–based metabolic analyses were conducted to find maker metabolites in serum and urine according to different SC types. Although some samples were overlapped on orthogonal projection to latent structure discriminant analysis score plots, serum samples showed separation between different SC types. Levels of lactate, glutamate, triglyceride, and fatty acids in serum and glycolic acid in urine of Tae-Eum type were higher than those of So-Eum and So-Yang type. Fatty acids, triglyceride, and lactate levels were found to be metabolites related to body mass index, indicating that marker metabolites for the diagnosis of SC type could be associated with obese. However, Tae-Eum type showed higher lactate levels in serum than So-Yang type for both normal weight and overweight groups, suggesting that the contents of serum lactate might be dependent on the SC type regardless of body weight. These results suggest that metabolomics analysis could be used to determine SC type.
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spelling pubmed-63780312019-03-10 Metabolite Markers for Characterizing Sasang Constitution Type through GC-MS and (1)H NMR-Based Metabolomics Study Kim, Eun-Ju Hong, Young-Shick Seo, Seung-Ho Park, Seong-Eun Na, Chang-Su Son, Hong-Seok Evid Based Complement Alternat Med Research Article Sasang constitutional medicine classifies human beings into four types based on their physical and psychological characteristics. Despite its potential value in achieving personalized medicine, the diagnosis of sasang constitution (SC) type is complex and subjective. In this study, gas chromatography–mass spectrometry and (1)H nuclear magnetic resonance–based metabolic analyses were conducted to find maker metabolites in serum and urine according to different SC types. Although some samples were overlapped on orthogonal projection to latent structure discriminant analysis score plots, serum samples showed separation between different SC types. Levels of lactate, glutamate, triglyceride, and fatty acids in serum and glycolic acid in urine of Tae-Eum type were higher than those of So-Eum and So-Yang type. Fatty acids, triglyceride, and lactate levels were found to be metabolites related to body mass index, indicating that marker metabolites for the diagnosis of SC type could be associated with obese. However, Tae-Eum type showed higher lactate levels in serum than So-Yang type for both normal weight and overweight groups, suggesting that the contents of serum lactate might be dependent on the SC type regardless of body weight. These results suggest that metabolomics analysis could be used to determine SC type. Hindawi 2019-02-03 /pmc/articles/PMC6378031/ /pubmed/30854017 http://dx.doi.org/10.1155/2019/8783496 Text en Copyright © 2019 Eun-Ju Kim et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kim, Eun-Ju
Hong, Young-Shick
Seo, Seung-Ho
Park, Seong-Eun
Na, Chang-Su
Son, Hong-Seok
Metabolite Markers for Characterizing Sasang Constitution Type through GC-MS and (1)H NMR-Based Metabolomics Study
title Metabolite Markers for Characterizing Sasang Constitution Type through GC-MS and (1)H NMR-Based Metabolomics Study
title_full Metabolite Markers for Characterizing Sasang Constitution Type through GC-MS and (1)H NMR-Based Metabolomics Study
title_fullStr Metabolite Markers for Characterizing Sasang Constitution Type through GC-MS and (1)H NMR-Based Metabolomics Study
title_full_unstemmed Metabolite Markers for Characterizing Sasang Constitution Type through GC-MS and (1)H NMR-Based Metabolomics Study
title_short Metabolite Markers for Characterizing Sasang Constitution Type through GC-MS and (1)H NMR-Based Metabolomics Study
title_sort metabolite markers for characterizing sasang constitution type through gc-ms and (1)h nmr-based metabolomics study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378031/
https://www.ncbi.nlm.nih.gov/pubmed/30854017
http://dx.doi.org/10.1155/2019/8783496
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