Asymmetrical and Isolated Hypoglossal Nerve Palsy Accompanied by a New Subset of Anti-ganglioside Antibodies in a Patient with Diffuse Large B Cell Lymphoma

Malignant lymphoma sometimes involves peripheral nerves due to paraneoplastic syndrome associated with anti-ganglioside antibodies. We report a very rare case of malignant lymphoma accompanied by an asymmetrical and isolated hypoglossal nerve palsy associated with a new subset of anti-ganglioside an...

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Autores principales: Ohta, Yasuyuki, Kawahara, Yuko, Tadokoro, Koh, Sato, Kota, Sasaki, Ryo, Takahashi, Yoshiaki, Takemoto, Mami, Hishikawa, Nozomi, Yamashita, Toru, Asano, Takeru, Inomata, Tomoko, Abe, Koji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378144/
https://www.ncbi.nlm.nih.gov/pubmed/30146587
http://dx.doi.org/10.2169/internalmedicine.1269-18
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author Ohta, Yasuyuki
Kawahara, Yuko
Tadokoro, Koh
Sato, Kota
Sasaki, Ryo
Takahashi, Yoshiaki
Takemoto, Mami
Hishikawa, Nozomi
Yamashita, Toru
Asano, Takeru
Inomata, Tomoko
Abe, Koji
author_facet Ohta, Yasuyuki
Kawahara, Yuko
Tadokoro, Koh
Sato, Kota
Sasaki, Ryo
Takahashi, Yoshiaki
Takemoto, Mami
Hishikawa, Nozomi
Yamashita, Toru
Asano, Takeru
Inomata, Tomoko
Abe, Koji
author_sort Ohta, Yasuyuki
collection PubMed
description Malignant lymphoma sometimes involves peripheral nerves due to paraneoplastic syndrome associated with anti-ganglioside antibodies. We report a very rare case of malignant lymphoma accompanied by an asymmetrical and isolated hypoglossal nerve palsy associated with a new subset of anti-ganglioside antibodies. Magnetic resonance imaging and (18)F-2-deoxy-2-fluoro-D-glucose position emission tomography showed no abnormalities of the hypoglossal nerve nucleus; however, the patient’s serum was positive for anti-sulfated glucuronyl paragloboside IgM antibodies as well as anti-GM1 IgM and anti-GQ1b IgM antibodies. The present case might suggest a paraneoplastic asymmetrical and isolated hypoglossal nerve palsy associated with a new subset of anti-ganglioside antibodies.
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spelling pubmed-63781442019-02-21 Asymmetrical and Isolated Hypoglossal Nerve Palsy Accompanied by a New Subset of Anti-ganglioside Antibodies in a Patient with Diffuse Large B Cell Lymphoma Ohta, Yasuyuki Kawahara, Yuko Tadokoro, Koh Sato, Kota Sasaki, Ryo Takahashi, Yoshiaki Takemoto, Mami Hishikawa, Nozomi Yamashita, Toru Asano, Takeru Inomata, Tomoko Abe, Koji Intern Med Case Report Malignant lymphoma sometimes involves peripheral nerves due to paraneoplastic syndrome associated with anti-ganglioside antibodies. We report a very rare case of malignant lymphoma accompanied by an asymmetrical and isolated hypoglossal nerve palsy associated with a new subset of anti-ganglioside antibodies. Magnetic resonance imaging and (18)F-2-deoxy-2-fluoro-D-glucose position emission tomography showed no abnormalities of the hypoglossal nerve nucleus; however, the patient’s serum was positive for anti-sulfated glucuronyl paragloboside IgM antibodies as well as anti-GM1 IgM and anti-GQ1b IgM antibodies. The present case might suggest a paraneoplastic asymmetrical and isolated hypoglossal nerve palsy associated with a new subset of anti-ganglioside antibodies. The Japanese Society of Internal Medicine 2018-08-24 2019-01-15 /pmc/articles/PMC6378144/ /pubmed/30146587 http://dx.doi.org/10.2169/internalmedicine.1269-18 Text en Copyright © 2019 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Ohta, Yasuyuki
Kawahara, Yuko
Tadokoro, Koh
Sato, Kota
Sasaki, Ryo
Takahashi, Yoshiaki
Takemoto, Mami
Hishikawa, Nozomi
Yamashita, Toru
Asano, Takeru
Inomata, Tomoko
Abe, Koji
Asymmetrical and Isolated Hypoglossal Nerve Palsy Accompanied by a New Subset of Anti-ganglioside Antibodies in a Patient with Diffuse Large B Cell Lymphoma
title Asymmetrical and Isolated Hypoglossal Nerve Palsy Accompanied by a New Subset of Anti-ganglioside Antibodies in a Patient with Diffuse Large B Cell Lymphoma
title_full Asymmetrical and Isolated Hypoglossal Nerve Palsy Accompanied by a New Subset of Anti-ganglioside Antibodies in a Patient with Diffuse Large B Cell Lymphoma
title_fullStr Asymmetrical and Isolated Hypoglossal Nerve Palsy Accompanied by a New Subset of Anti-ganglioside Antibodies in a Patient with Diffuse Large B Cell Lymphoma
title_full_unstemmed Asymmetrical and Isolated Hypoglossal Nerve Palsy Accompanied by a New Subset of Anti-ganglioside Antibodies in a Patient with Diffuse Large B Cell Lymphoma
title_short Asymmetrical and Isolated Hypoglossal Nerve Palsy Accompanied by a New Subset of Anti-ganglioside Antibodies in a Patient with Diffuse Large B Cell Lymphoma
title_sort asymmetrical and isolated hypoglossal nerve palsy accompanied by a new subset of anti-ganglioside antibodies in a patient with diffuse large b cell lymphoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378144/
https://www.ncbi.nlm.nih.gov/pubmed/30146587
http://dx.doi.org/10.2169/internalmedicine.1269-18
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