The Progression of Esophageal Mucosa-associated Lymphoid Tissue Lymphoma after Helicobacter pylori Eradication Therapy: A Case Report and Discussion of Therapeutic Options

A 50-year-old woman with epigastric discomfort was referred to our hospital. Esophagogastroduodenoscopy showed flat, elevated, submucosal tumor-like lesions in the esophagus. Extranodal marginal zone lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma) of the esophagus was diagnosed bas...

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Autores principales: Takeuchi, Yukari, Miyahara, Koji, Morito, Toshiaki, Okikawa, Yoshiko, Kinugasa, Hideaki, Moritou, Yuki, Higashi, Reiji, Kunihiro, Masaki, Nakagawa, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378146/
https://www.ncbi.nlm.nih.gov/pubmed/30146577
http://dx.doi.org/10.2169/internalmedicine.1112-18
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author Takeuchi, Yukari
Miyahara, Koji
Morito, Toshiaki
Okikawa, Yoshiko
Kinugasa, Hideaki
Moritou, Yuki
Higashi, Reiji
Kunihiro, Masaki
Nakagawa, Masahiro
author_facet Takeuchi, Yukari
Miyahara, Koji
Morito, Toshiaki
Okikawa, Yoshiko
Kinugasa, Hideaki
Moritou, Yuki
Higashi, Reiji
Kunihiro, Masaki
Nakagawa, Masahiro
author_sort Takeuchi, Yukari
collection PubMed
description A 50-year-old woman with epigastric discomfort was referred to our hospital. Esophagogastroduodenoscopy showed flat, elevated, submucosal tumor-like lesions in the esophagus. Extranodal marginal zone lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma) of the esophagus was diagnosed based on the examination of an endoscopic biopsy specimen. Computed tomography showed the enlargement of a lymph node in the gastric cardia. The present case showed disease progression despite Helicobacter pylori eradication therapy and achieved partial remission after rituximab monotherapy. The patient remained in partial remission for 20 months. This case suggests that esophageal MALT lymphoma with lymph node involvement does not respond to H. pylori eradication therapy and that it requires systemic treatment.
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spelling pubmed-63781462019-02-21 The Progression of Esophageal Mucosa-associated Lymphoid Tissue Lymphoma after Helicobacter pylori Eradication Therapy: A Case Report and Discussion of Therapeutic Options Takeuchi, Yukari Miyahara, Koji Morito, Toshiaki Okikawa, Yoshiko Kinugasa, Hideaki Moritou, Yuki Higashi, Reiji Kunihiro, Masaki Nakagawa, Masahiro Intern Med Case Report A 50-year-old woman with epigastric discomfort was referred to our hospital. Esophagogastroduodenoscopy showed flat, elevated, submucosal tumor-like lesions in the esophagus. Extranodal marginal zone lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma) of the esophagus was diagnosed based on the examination of an endoscopic biopsy specimen. Computed tomography showed the enlargement of a lymph node in the gastric cardia. The present case showed disease progression despite Helicobacter pylori eradication therapy and achieved partial remission after rituximab monotherapy. The patient remained in partial remission for 20 months. This case suggests that esophageal MALT lymphoma with lymph node involvement does not respond to H. pylori eradication therapy and that it requires systemic treatment. The Japanese Society of Internal Medicine 2018-08-24 2019-01-15 /pmc/articles/PMC6378146/ /pubmed/30146577 http://dx.doi.org/10.2169/internalmedicine.1112-18 Text en Copyright © 2019 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Takeuchi, Yukari
Miyahara, Koji
Morito, Toshiaki
Okikawa, Yoshiko
Kinugasa, Hideaki
Moritou, Yuki
Higashi, Reiji
Kunihiro, Masaki
Nakagawa, Masahiro
The Progression of Esophageal Mucosa-associated Lymphoid Tissue Lymphoma after Helicobacter pylori Eradication Therapy: A Case Report and Discussion of Therapeutic Options
title The Progression of Esophageal Mucosa-associated Lymphoid Tissue Lymphoma after Helicobacter pylori Eradication Therapy: A Case Report and Discussion of Therapeutic Options
title_full The Progression of Esophageal Mucosa-associated Lymphoid Tissue Lymphoma after Helicobacter pylori Eradication Therapy: A Case Report and Discussion of Therapeutic Options
title_fullStr The Progression of Esophageal Mucosa-associated Lymphoid Tissue Lymphoma after Helicobacter pylori Eradication Therapy: A Case Report and Discussion of Therapeutic Options
title_full_unstemmed The Progression of Esophageal Mucosa-associated Lymphoid Tissue Lymphoma after Helicobacter pylori Eradication Therapy: A Case Report and Discussion of Therapeutic Options
title_short The Progression of Esophageal Mucosa-associated Lymphoid Tissue Lymphoma after Helicobacter pylori Eradication Therapy: A Case Report and Discussion of Therapeutic Options
title_sort progression of esophageal mucosa-associated lymphoid tissue lymphoma after helicobacter pylori eradication therapy: a case report and discussion of therapeutic options
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378146/
https://www.ncbi.nlm.nih.gov/pubmed/30146577
http://dx.doi.org/10.2169/internalmedicine.1112-18
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