Type 1 Diabetes Mellitus and Klinefelter Syndrome

A 60-year-old male patient with type 1 diabetes mellitus (T1DM) was admitted for glycemic control. The patient exhibited abdominal adiposity, osteoporosis, and high insulin requirement (＞100 U), and we suspected hypogonadism. A physical examination revealed small testes and thin pubic hair, laborato...

Descripción completa

Detalles Bibliográficos
Autores principales: Sakurai, Teruaki, Iizuka, Katsumi, Kato, Takehiro, Takeda, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378147/
https://www.ncbi.nlm.nih.gov/pubmed/30146555
http://dx.doi.org/10.2169/internalmedicine.1051-18
Descripción
Sumario:A 60-year-old male patient with type 1 diabetes mellitus (T1DM) was admitted for glycemic control. The patient exhibited abdominal adiposity, osteoporosis, and high insulin requirement (＞100 U), and we suspected hypogonadism. A physical examination revealed small testes and thin pubic hair, laboratory examination found high luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels and low testosterone levels, and a chromosome analysis (47, XXY) indicated hypogonadism due to Klinefelter syndrome (KS). KS is associated with autoimmune diseases and patients positive for diabetes related auto-antibodies. In male patients with T1DM and abdominal adiposity, the concurrence of KS should be taken into consideration.

Ejemplares similares