Type 1 Diabetes Mellitus and Klinefelter Syndrome

A 60-year-old male patient with type 1 diabetes mellitus (T1DM) was admitted for glycemic control. The patient exhibited abdominal adiposity, osteoporosis, and high insulin requirement (＞100 U), and we suspected hypogonadism. A physical examination revealed small testes and thin pubic hair, laborato...

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Detalles Bibliográficos
Autores principales: Sakurai, Teruaki, Iizuka, Katsumi, Kato, Takehiro, Takeda, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378147/
https://www.ncbi.nlm.nih.gov/pubmed/30146555
http://dx.doi.org/10.2169/internalmedicine.1051-18
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author Sakurai, Teruaki
Iizuka, Katsumi
Kato, Takehiro
Takeda, Jun
author_facet Sakurai, Teruaki
Iizuka, Katsumi
Kato, Takehiro
Takeda, Jun
author_sort Sakurai, Teruaki
collection PubMed
description A 60-year-old male patient with type 1 diabetes mellitus (T1DM) was admitted for glycemic control. The patient exhibited abdominal adiposity, osteoporosis, and high insulin requirement (＞100 U), and we suspected hypogonadism. A physical examination revealed small testes and thin pubic hair, laboratory examination found high luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels and low testosterone levels, and a chromosome analysis (47, XXY) indicated hypogonadism due to Klinefelter syndrome (KS). KS is associated with autoimmune diseases and patients positive for diabetes related auto-antibodies. In male patients with T1DM and abdominal adiposity, the concurrence of KS should be taken into consideration.
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spelling pubmed-63781472019-02-21 Type 1 Diabetes Mellitus and Klinefelter Syndrome Sakurai, Teruaki Iizuka, Katsumi Kato, Takehiro Takeda, Jun Intern Med Case Report A 60-year-old male patient with type 1 diabetes mellitus (T1DM) was admitted for glycemic control. The patient exhibited abdominal adiposity, osteoporosis, and high insulin requirement (＞100 U), and we suspected hypogonadism. A physical examination revealed small testes and thin pubic hair, laboratory examination found high luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels and low testosterone levels, and a chromosome analysis (47, XXY) indicated hypogonadism due to Klinefelter syndrome (KS). KS is associated with autoimmune diseases and patients positive for diabetes related auto-antibodies. In male patients with T1DM and abdominal adiposity, the concurrence of KS should be taken into consideration. The Japanese Society of Internal Medicine 2018-08-24 2019-01-15 /pmc/articles/PMC6378147/ /pubmed/30146555 http://dx.doi.org/10.2169/internalmedicine.1051-18 Text en Copyright © 2019 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Sakurai, Teruaki
Iizuka, Katsumi
Kato, Takehiro
Takeda, Jun
Type 1 Diabetes Mellitus and Klinefelter Syndrome
title Type 1 Diabetes Mellitus and Klinefelter Syndrome
title_full Type 1 Diabetes Mellitus and Klinefelter Syndrome
title_fullStr Type 1 Diabetes Mellitus and Klinefelter Syndrome
title_full_unstemmed Type 1 Diabetes Mellitus and Klinefelter Syndrome
title_short Type 1 Diabetes Mellitus and Klinefelter Syndrome
title_sort type 1 diabetes mellitus and klinefelter syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378147/
https://www.ncbi.nlm.nih.gov/pubmed/30146555
http://dx.doi.org/10.2169/internalmedicine.1051-18
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