Targeting the lysosome by an aminomethylated Riccardin D triggers DNA damage through cathepsin B‐mediated degradation of BRCA1

RD‐N, an aminomethylated derivative of riccardin D, is a lysosomotropic agent that can trigger lysosomal membrane permeabilization followed by cathepsin B (CTSB)‐dependent apoptosis in prostate cancer (PCa) cells, but the underlying mechanisms remain unknown. Here we show that RD‐N treatment drives...

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Detalles Bibliográficos
Autores principales: Wang, Yanyan, Niu, Huanmin, Hu, Zhongyi, Zhu, Mengyuan, Wang, Lining, Han, Lili, Qian, Lilin, Tian, Keli, Yuan, Huiqing, Lou, Hongxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378192/
https://www.ncbi.nlm.nih.gov/pubmed/30565390
http://dx.doi.org/10.1111/jcmm.14077

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