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Granulocytic myeloid‐derived suppressor cell population increases with the severity of alcoholic liver disease
Alcoholic liver disease (ALD) is a progressive liver disease that can cause a series of complications, including cirrhosis, liver failure and hepatocellular carcinoma. Granulocytic myeloid‐derived suppressor cell (gMDSC) populations have been observed to expand in various liver diseases and to inhib...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378203/ https://www.ncbi.nlm.nih.gov/pubmed/30585398 http://dx.doi.org/10.1111/jcmm.14109 |
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author | Gao, Miaomiao Huang, Ang Sun, Zijian Sun, Ying Chang, Binxia Zhang, Ji‐yuan Zou, Zheng‐sheng |
author_facet | Gao, Miaomiao Huang, Ang Sun, Zijian Sun, Ying Chang, Binxia Zhang, Ji‐yuan Zou, Zheng‐sheng |
author_sort | Gao, Miaomiao |
collection | PubMed |
description | Alcoholic liver disease (ALD) is a progressive liver disease that can cause a series of complications, including cirrhosis, liver failure and hepatocellular carcinoma. Granulocytic myeloid‐derived suppressor cell (gMDSC) populations have been observed to expand in various liver diseases and to inhibit innate and adaptive immunity in patients with liver disease. However, the characteristics of gMDSCs in patients with ALD have not been studied. We studied 24 healthy controls (HCs) and 107 patients with ALD and found an accumulation of gMDSCs in the peripheral blood of patients with alcoholic liver cirrhosis (ALC). Furthermore, ALC patients with a poor prognosis displayed a significant increase in peripheral gMDSCs and showed an increased capacity for arginase I production compared to HCs. In contrast, plasma arginase I levels in ALC patients were negatively correlated with total bilirubin and international normalized ratio, two key parameters of liver damage. Importantly, gMDSCs accumulated in the livers of ALC patients, and the frequency of liver gMDSCs significantly correlated with that of peripheral gMDSCs. In addition, gMDSC enrichment in vitro significantly inhibited the function of natural killer (NK) cells, perhaps preventing the NK‐induced apoptosis of hepatic stellate cells. In summary, increased peripheral and intrahepatic gMDSC populations are present in patients with ALC and may contribute to enhancing the severity of liver cirrhosis. |
format | Online Article Text |
id | pubmed-6378203 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-63782032019-03-01 Granulocytic myeloid‐derived suppressor cell population increases with the severity of alcoholic liver disease Gao, Miaomiao Huang, Ang Sun, Zijian Sun, Ying Chang, Binxia Zhang, Ji‐yuan Zou, Zheng‐sheng J Cell Mol Med Original Articles Alcoholic liver disease (ALD) is a progressive liver disease that can cause a series of complications, including cirrhosis, liver failure and hepatocellular carcinoma. Granulocytic myeloid‐derived suppressor cell (gMDSC) populations have been observed to expand in various liver diseases and to inhibit innate and adaptive immunity in patients with liver disease. However, the characteristics of gMDSCs in patients with ALD have not been studied. We studied 24 healthy controls (HCs) and 107 patients with ALD and found an accumulation of gMDSCs in the peripheral blood of patients with alcoholic liver cirrhosis (ALC). Furthermore, ALC patients with a poor prognosis displayed a significant increase in peripheral gMDSCs and showed an increased capacity for arginase I production compared to HCs. In contrast, plasma arginase I levels in ALC patients were negatively correlated with total bilirubin and international normalized ratio, two key parameters of liver damage. Importantly, gMDSCs accumulated in the livers of ALC patients, and the frequency of liver gMDSCs significantly correlated with that of peripheral gMDSCs. In addition, gMDSC enrichment in vitro significantly inhibited the function of natural killer (NK) cells, perhaps preventing the NK‐induced apoptosis of hepatic stellate cells. In summary, increased peripheral and intrahepatic gMDSC populations are present in patients with ALC and may contribute to enhancing the severity of liver cirrhosis. John Wiley and Sons Inc. 2018-12-25 2019-03 /pmc/articles/PMC6378203/ /pubmed/30585398 http://dx.doi.org/10.1111/jcmm.14109 Text en © 2018 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Gao, Miaomiao Huang, Ang Sun, Zijian Sun, Ying Chang, Binxia Zhang, Ji‐yuan Zou, Zheng‐sheng Granulocytic myeloid‐derived suppressor cell population increases with the severity of alcoholic liver disease |
title | Granulocytic myeloid‐derived suppressor cell population increases with the severity of alcoholic liver disease |
title_full | Granulocytic myeloid‐derived suppressor cell population increases with the severity of alcoholic liver disease |
title_fullStr | Granulocytic myeloid‐derived suppressor cell population increases with the severity of alcoholic liver disease |
title_full_unstemmed | Granulocytic myeloid‐derived suppressor cell population increases with the severity of alcoholic liver disease |
title_short | Granulocytic myeloid‐derived suppressor cell population increases with the severity of alcoholic liver disease |
title_sort | granulocytic myeloid‐derived suppressor cell population increases with the severity of alcoholic liver disease |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378203/ https://www.ncbi.nlm.nih.gov/pubmed/30585398 http://dx.doi.org/10.1111/jcmm.14109 |
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