Trabecular meshwork cells are a valuable resource for cellular therapy of glaucoma

Trabecular meshwork (TM) contains a subset of adult stem cells or progenitors that can be differentiated into corneal endothelial cells, adipocytes and chondrocytes, but not osteocytes or keratocytes. Accordingly, these progenitors can be utilized as a cell‐based therapy to prevent blindness caused...

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Detalles Bibliográficos
Autores principales: Sun, Hong, Zhu, Qin, Guo, Ping, Zhang, Yuan, Tighe, Sean, Zhu, Yingting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378204/
https://www.ncbi.nlm.nih.gov/pubmed/30659738
http://dx.doi.org/10.1111/jcmm.14158
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author Sun, Hong
Zhu, Qin
Guo, Ping
Zhang, Yuan
Tighe, Sean
Zhu, Yingting
author_facet Sun, Hong
Zhu, Qin
Guo, Ping
Zhang, Yuan
Tighe, Sean
Zhu, Yingting
author_sort Sun, Hong
collection PubMed
description Trabecular meshwork (TM) contains a subset of adult stem cells or progenitors that can be differentiated into corneal endothelial cells, adipocytes and chondrocytes, but not osteocytes or keratocytes. Accordingly, these progenitors can be utilized as a cell‐based therapy to prevent blindness caused by glaucoma, corneal endothelial dysfunction and other diseases in general. In this review, we review in vitro expansion techniques for TM progenitors, discuss their phenotypic properties, and highlight their potential clinical applications in various ophthalmic diseases.
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spelling pubmed-63782042019-03-01 Trabecular meshwork cells are a valuable resource for cellular therapy of glaucoma Sun, Hong Zhu, Qin Guo, Ping Zhang, Yuan Tighe, Sean Zhu, Yingting J Cell Mol Med Reviews Trabecular meshwork (TM) contains a subset of adult stem cells or progenitors that can be differentiated into corneal endothelial cells, adipocytes and chondrocytes, but not osteocytes or keratocytes. Accordingly, these progenitors can be utilized as a cell‐based therapy to prevent blindness caused by glaucoma, corneal endothelial dysfunction and other diseases in general. In this review, we review in vitro expansion techniques for TM progenitors, discuss their phenotypic properties, and highlight their potential clinical applications in various ophthalmic diseases. John Wiley and Sons Inc. 2019-01-18 2019-03 /pmc/articles/PMC6378204/ /pubmed/30659738 http://dx.doi.org/10.1111/jcmm.14158 Text en © 2019 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Sun, Hong
Zhu, Qin
Guo, Ping
Zhang, Yuan
Tighe, Sean
Zhu, Yingting
Trabecular meshwork cells are a valuable resource for cellular therapy of glaucoma
title Trabecular meshwork cells are a valuable resource for cellular therapy of glaucoma
title_full Trabecular meshwork cells are a valuable resource for cellular therapy of glaucoma
title_fullStr Trabecular meshwork cells are a valuable resource for cellular therapy of glaucoma
title_full_unstemmed Trabecular meshwork cells are a valuable resource for cellular therapy of glaucoma
title_short Trabecular meshwork cells are a valuable resource for cellular therapy of glaucoma
title_sort trabecular meshwork cells are a valuable resource for cellular therapy of glaucoma
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378204/
https://www.ncbi.nlm.nih.gov/pubmed/30659738
http://dx.doi.org/10.1111/jcmm.14158
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