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Should heart rate variability be “corrected” for heart rate? Biological, quantitative, and interpretive considerations

Metrics of heart period variability are widely used in the behavioral and biomedical sciences, although somewhat confusingly labeled as heart rate variability (HRV). Despite their wide use, HRV metrics are usually analyzed and interpreted without reference to prevailing levels of cardiac chronotropi...

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Autores principales: de Geus, Eco J. C., Gianaros, Peter J., Brindle, Ryan C., Jennings, J. Richard, Berntson, Gary G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378407/
https://www.ncbi.nlm.nih.gov/pubmed/30357862
http://dx.doi.org/10.1111/psyp.13287
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author de Geus, Eco J. C.
Gianaros, Peter J.
Brindle, Ryan C.
Jennings, J. Richard
Berntson, Gary G.
author_facet de Geus, Eco J. C.
Gianaros, Peter J.
Brindle, Ryan C.
Jennings, J. Richard
Berntson, Gary G.
author_sort de Geus, Eco J. C.
collection PubMed
description Metrics of heart period variability are widely used in the behavioral and biomedical sciences, although somewhat confusingly labeled as heart rate variability (HRV). Despite their wide use, HRV metrics are usually analyzed and interpreted without reference to prevailing levels of cardiac chronotropic state (i.e., mean heart rate or mean heart period). This isolated treatment of HRV metrics is nontrivial. All HRV metrics routinely used in the literature exhibit a known and positive relationship with the mean duration of the interval between two beats (heart period): as the heart period increases, so does its variability. This raises the question of whether HRV metrics should be “corrected” for the mean heart period (or its inverse, the heart rate). Here, we outline biological, quantitative, and interpretive issues engendered by this question. We provide arguments that HRV is neither uniformly nor simply a surrogate for heart period. We also identify knowledge gaps that remain to be satisfactorily addressed with respect to assumptions underlying existing HRV correction approaches. In doing so, we aim to stimulate further progress toward the rigorous use and disciplined interpretation of HRV. We close with provisional guidance on HRV reporting that acknowledges the complex interplay between the mean and variability of the heart period.
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spelling pubmed-63784072019-02-28 Should heart rate variability be “corrected” for heart rate? Biological, quantitative, and interpretive considerations de Geus, Eco J. C. Gianaros, Peter J. Brindle, Ryan C. Jennings, J. Richard Berntson, Gary G. Psychophysiology Review Metrics of heart period variability are widely used in the behavioral and biomedical sciences, although somewhat confusingly labeled as heart rate variability (HRV). Despite their wide use, HRV metrics are usually analyzed and interpreted without reference to prevailing levels of cardiac chronotropic state (i.e., mean heart rate or mean heart period). This isolated treatment of HRV metrics is nontrivial. All HRV metrics routinely used in the literature exhibit a known and positive relationship with the mean duration of the interval between two beats (heart period): as the heart period increases, so does its variability. This raises the question of whether HRV metrics should be “corrected” for the mean heart period (or its inverse, the heart rate). Here, we outline biological, quantitative, and interpretive issues engendered by this question. We provide arguments that HRV is neither uniformly nor simply a surrogate for heart period. We also identify knowledge gaps that remain to be satisfactorily addressed with respect to assumptions underlying existing HRV correction approaches. In doing so, we aim to stimulate further progress toward the rigorous use and disciplined interpretation of HRV. We close with provisional guidance on HRV reporting that acknowledges the complex interplay between the mean and variability of the heart period. John Wiley and Sons Inc. 2018-10-25 2019-02 /pmc/articles/PMC6378407/ /pubmed/30357862 http://dx.doi.org/10.1111/psyp.13287 Text en © 2018 The Authors Psychophysiology published by Wiley Periodicals, Inc. on behalf of Society for Psychophysiological Research This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
de Geus, Eco J. C.
Gianaros, Peter J.
Brindle, Ryan C.
Jennings, J. Richard
Berntson, Gary G.
Should heart rate variability be “corrected” for heart rate? Biological, quantitative, and interpretive considerations
title Should heart rate variability be “corrected” for heart rate? Biological, quantitative, and interpretive considerations
title_full Should heart rate variability be “corrected” for heart rate? Biological, quantitative, and interpretive considerations
title_fullStr Should heart rate variability be “corrected” for heart rate? Biological, quantitative, and interpretive considerations
title_full_unstemmed Should heart rate variability be “corrected” for heart rate? Biological, quantitative, and interpretive considerations
title_short Should heart rate variability be “corrected” for heart rate? Biological, quantitative, and interpretive considerations
title_sort should heart rate variability be “corrected” for heart rate? biological, quantitative, and interpretive considerations
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378407/
https://www.ncbi.nlm.nih.gov/pubmed/30357862
http://dx.doi.org/10.1111/psyp.13287
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