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The Role of APOE4 in Disrupting the Homeostatic Functions of Astrocytes and Microglia in Aging and Alzheimer’s Disease

APOE4 is the greatest genetic risk factor for late-onset Alzheimer’s disease (AD), increasing the risk of developing the disease by 3-fold in the 14% of the population that are carriers. Despite 25 years of research, the exact mechanisms underlying how APOE4 contributes to AD pathogenesis remain inc...

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Detalles Bibliográficos
Autores principales:	Fernandez, Celia G., Hamby, Mary E., McReynolds, Morgan L., Ray, William J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378415/ https://www.ncbi.nlm.nih.gov/pubmed/30804776 http://dx.doi.org/10.3389/fnagi.2019.00014

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