LDK378 improves micro- and macro-circulation via alleviating STING-mediated inflammatory injury in a Sepsis rat model induced by Cecal ligation and puncture

BACKGROUND: Sepsis is a systemic inflammatory response syndrome caused by severe infections. LDK378, a second-generation ALK inhibitor, exhibits a potential anti-inflammatory function against sepsis. Micro- and macro-circulatory dysfunctions are pivotal elements of the pathogenesis of severe sepsis...

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Detalles Bibliográficos
Autores principales: Ge, Weiwei, Hu, Qiaohua, Fang, Xiangshao, Liu, Juanhua, Xu, Jing, Hu, Juntao, Liu, Xuefen, Ling, Qin, Wang, Yue, Li, He, Gao, Ming, Jiang, Longyuan, Yang, Zhengfei, Tang, Wanchun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378711/
https://www.ncbi.nlm.nih.gov/pubmed/30820191
http://dx.doi.org/10.1186/s12950-019-0208-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378711/
https://www.ncbi.nlm.nih.gov/pubmed/30820191
http://dx.doi.org/10.1186/s12950-019-0208-0

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