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LDK378 improves micro- and macro-circulation via alleviating STING-mediated inflammatory injury in a Sepsis rat model induced by Cecal ligation and puncture

BACKGROUND: Sepsis is a systemic inflammatory response syndrome caused by severe infections. LDK378, a second-generation ALK inhibitor, exhibits a potential anti-inflammatory function against sepsis. Micro- and macro-circulatory dysfunctions are pivotal elements of the pathogenesis of severe sepsis...

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Detalles Bibliográficos
Autores principales:	Ge, Weiwei, Hu, Qiaohua, Fang, Xiangshao, Liu, Juanhua, Xu, Jing, Hu, Juntao, Liu, Xuefen, Ling, Qin, Wang, Yue, Li, He, Gao, Ming, Jiang, Longyuan, Yang, Zhengfei, Tang, Wanchun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378711/ https://www.ncbi.nlm.nih.gov/pubmed/30820191 http://dx.doi.org/10.1186/s12950-019-0208-0

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