Statistical assessment and visualization of synergies for large-scale sparse drug combination datasets

BACKGROUND: Drug combinations have the potential to improve efficacy while limiting toxicity. To robustly identify synergistic combinations, high-throughput screens using full dose-response surface are desirable but require an impractical number of data points. Screening of a sparse number of doses...

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Detalles Bibliográficos
Autores principales: Amzallag, Arnaud, Ramaswamy, Sridhar, Benes, Cyril H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378741/
https://www.ncbi.nlm.nih.gov/pubmed/30777010
http://dx.doi.org/10.1186/s12859-019-2642-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378741/
https://www.ncbi.nlm.nih.gov/pubmed/30777010
http://dx.doi.org/10.1186/s12859-019-2642-7

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