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Statistical assessment and visualization of synergies for large-scale sparse drug combination datasets
BACKGROUND: Drug combinations have the potential to improve efficacy while limiting toxicity. To robustly identify synergistic combinations, high-throughput screens using full dose-response surface are desirable but require an impractical number of data points. Screening of a sparse number of doses...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378741/ https://www.ncbi.nlm.nih.gov/pubmed/30777010 http://dx.doi.org/10.1186/s12859-019-2642-7 |