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Coupling of PARP1-mediated chromatin structural changes to transcriptional RNA polymerase II elongation and cotranscriptional splicing
BACKGROUND: Recently, we showed that PARP1 is involved in cotranscriptional splicing, possibly by bridging chromatin to RNA and recruiting splicing factors. It also can influence alternative splicing decisions through the regulation of RNAPII elongation. In this study, we investigated the effect of...
Autores principales: | Matveeva, Elena A., Al-Tinawi, Qamar M. H., Rouchka, Eric C., Fondufe-Mittendorf, Yvonne N. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378753/ https://www.ncbi.nlm.nih.gov/pubmed/30777121 http://dx.doi.org/10.1186/s13072-019-0261-1 |
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