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Pathological Implications of Receptor for Advanced Glycation End-Product (AGER) Gene Polymorphism
The receptor for advanced glycation end-products (RAGE) is a cell surface transmembrane multiligand receptor, encoded by the AGER gene. RAGE presents many transcripts, is expressed mainly in the lung, and involves multiple pathways (such as NFκB, Akt, p38, and MAP kinases) that initiate and perpetua...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378764/ https://www.ncbi.nlm.nih.gov/pubmed/30863465 http://dx.doi.org/10.1155/2019/2067353 |
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author | Serveaux-Dancer, Marine Jabaudon, Matthieu Creveaux, Isabelle Belville, Corinne Blondonnet, Raïko Gross, Christelle Constantin, Jean-Michel Blanchon, Loïc Sapin, Vincent |
author_facet | Serveaux-Dancer, Marine Jabaudon, Matthieu Creveaux, Isabelle Belville, Corinne Blondonnet, Raïko Gross, Christelle Constantin, Jean-Michel Blanchon, Loïc Sapin, Vincent |
author_sort | Serveaux-Dancer, Marine |
collection | PubMed |
description | The receptor for advanced glycation end-products (RAGE) is a cell surface transmembrane multiligand receptor, encoded by the AGER gene. RAGE presents many transcripts, is expressed mainly in the lung, and involves multiple pathways (such as NFκB, Akt, p38, and MAP kinases) that initiate and perpetuate an unfavorable proinflammatory state. Due to these numerous functional activities, RAGE is implicated in multiple diseases. AGER is a highly polymorphic gene, with polymorphisms or SNP (single-nucleotide polymorphism) that could be responsible or co-responsible for disease development. This review was designed to shed light on the pathological implications of AGER polymorphisms. Five polymorphisms are described: rs2070600, rs1800624, rs1800625, rs184003, and a 63 bp deletion. The rs2070600 SNP may be associated with the development of human autoimmune disease, diabetes complications, cancer, and lung diseases such as chronic obstructive pulmonary disease and acute respiratory distress syndrome. The rs1800624 SNP involves AGER gene regulation and may be related to reduced risk of heart disease, cancer, Crohn's disease, and type 1 diabetes complications. The rs1800625 SNP may be associated with the development of diabetic retinopathy, cancer, and lupus but may be protective against cardiovascular risk. The rs184003 SNP seems related to coronary artery disease, breast cancer, and diabetes. The 63 bp deletion may be associated with reduced survival from heart diseases during diabetic nephropathy. Here, these potential associations between AGER polymorphisms and the development of diseases are discussed, as there have been conflicting findings on the pathological impact of AGER SNPs in the literature. These contradictory results might be explained by distinct AGER SNP frequencies depending on ethnicity. |
format | Online Article Text |
id | pubmed-6378764 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-63787642019-03-12 Pathological Implications of Receptor for Advanced Glycation End-Product (AGER) Gene Polymorphism Serveaux-Dancer, Marine Jabaudon, Matthieu Creveaux, Isabelle Belville, Corinne Blondonnet, Raïko Gross, Christelle Constantin, Jean-Michel Blanchon, Loïc Sapin, Vincent Dis Markers Review Article The receptor for advanced glycation end-products (RAGE) is a cell surface transmembrane multiligand receptor, encoded by the AGER gene. RAGE presents many transcripts, is expressed mainly in the lung, and involves multiple pathways (such as NFκB, Akt, p38, and MAP kinases) that initiate and perpetuate an unfavorable proinflammatory state. Due to these numerous functional activities, RAGE is implicated in multiple diseases. AGER is a highly polymorphic gene, with polymorphisms or SNP (single-nucleotide polymorphism) that could be responsible or co-responsible for disease development. This review was designed to shed light on the pathological implications of AGER polymorphisms. Five polymorphisms are described: rs2070600, rs1800624, rs1800625, rs184003, and a 63 bp deletion. The rs2070600 SNP may be associated with the development of human autoimmune disease, diabetes complications, cancer, and lung diseases such as chronic obstructive pulmonary disease and acute respiratory distress syndrome. The rs1800624 SNP involves AGER gene regulation and may be related to reduced risk of heart disease, cancer, Crohn's disease, and type 1 diabetes complications. The rs1800625 SNP may be associated with the development of diabetic retinopathy, cancer, and lupus but may be protective against cardiovascular risk. The rs184003 SNP seems related to coronary artery disease, breast cancer, and diabetes. The 63 bp deletion may be associated with reduced survival from heart diseases during diabetic nephropathy. Here, these potential associations between AGER polymorphisms and the development of diseases are discussed, as there have been conflicting findings on the pathological impact of AGER SNPs in the literature. These contradictory results might be explained by distinct AGER SNP frequencies depending on ethnicity. Hindawi 2019-02-04 /pmc/articles/PMC6378764/ /pubmed/30863465 http://dx.doi.org/10.1155/2019/2067353 Text en Copyright © 2019 Marine Serveaux-Dancer et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Serveaux-Dancer, Marine Jabaudon, Matthieu Creveaux, Isabelle Belville, Corinne Blondonnet, Raïko Gross, Christelle Constantin, Jean-Michel Blanchon, Loïc Sapin, Vincent Pathological Implications of Receptor for Advanced Glycation End-Product (AGER) Gene Polymorphism |
title | Pathological Implications of Receptor for Advanced Glycation End-Product (AGER) Gene Polymorphism |
title_full | Pathological Implications of Receptor for Advanced Glycation End-Product (AGER) Gene Polymorphism |
title_fullStr | Pathological Implications of Receptor for Advanced Glycation End-Product (AGER) Gene Polymorphism |
title_full_unstemmed | Pathological Implications of Receptor for Advanced Glycation End-Product (AGER) Gene Polymorphism |
title_short | Pathological Implications of Receptor for Advanced Glycation End-Product (AGER) Gene Polymorphism |
title_sort | pathological implications of receptor for advanced glycation end-product (ager) gene polymorphism |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378764/ https://www.ncbi.nlm.nih.gov/pubmed/30863465 http://dx.doi.org/10.1155/2019/2067353 |
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