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Direct Observation of Topoisomerase IA Gate Dynamics

Type IA topoisomerases cleave single-stranded DNA and relieve negative supercoils in discrete steps corresponding to the passage of the intact DNA strand through the cleaved strand. Although it is assumed type IA topoisomerases accomplish this strand passage via a protein-mediated DNA gate, opening...

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Detalles Bibliográficos
Autores principales:	Mills, Maria, Tse-Dinh, Yuk-Ching, Neuman, Keir C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379066/ https://www.ncbi.nlm.nih.gov/pubmed/30478267 http://dx.doi.org/10.1038/s41594-018-0158-x

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