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Mi-2/NuRD complex protects stem cell progeny from mitogenic Notch signaling

To progress towards differentiation, progeny of stem cells need to extinguish expression of stem-cell maintenance genes. Failures in such mechanisms can drive tumorigenesis. In Drosophila neural stem cell (NSC) lineages, excessive Notch signalling results in supernumerary NSCs causing hyperplasia. H...

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Detalles Bibliográficos
Autores principales:	Zacharioudaki, Evanthia, Falo Sanjuan, Julia, Bray, Sarah
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Chromosomes and Gene Expression
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379090/ https://www.ncbi.nlm.nih.gov/pubmed/30694174 http://dx.doi.org/10.7554/eLife.41637

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