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MR Volumetry of Lung Nodules: A Pilot Study

Introduction: Computed tomography (CT) is currently the reference modality for the detection and follow-up of pulmonary nodules. While 2D measurements are commonly used in clinical practice to assess growth, increasingly 3D volume measurements are being recommended. The goal of this pilot study was...

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Autores principales: Delacoste, Jean, Dunet, Vincent, Dournes, Gael, Lovis, Alban, Rohner, Chantal, Elandoy, Christel, Simons, Julien, Long, Olivier, Piccini, Davide, Stuber, Matthias, Prior, John O., Nicod, Laurent, Beigelman-Aubry, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379285/
https://www.ncbi.nlm.nih.gov/pubmed/30809522
http://dx.doi.org/10.3389/fmed.2019.00018
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author Delacoste, Jean
Dunet, Vincent
Dournes, Gael
Lovis, Alban
Rohner, Chantal
Elandoy, Christel
Simons, Julien
Long, Olivier
Piccini, Davide
Stuber, Matthias
Prior, John O.
Nicod, Laurent
Beigelman-Aubry, Catherine
author_facet Delacoste, Jean
Dunet, Vincent
Dournes, Gael
Lovis, Alban
Rohner, Chantal
Elandoy, Christel
Simons, Julien
Long, Olivier
Piccini, Davide
Stuber, Matthias
Prior, John O.
Nicod, Laurent
Beigelman-Aubry, Catherine
author_sort Delacoste, Jean
collection PubMed
description Introduction: Computed tomography (CT) is currently the reference modality for the detection and follow-up of pulmonary nodules. While 2D measurements are commonly used in clinical practice to assess growth, increasingly 3D volume measurements are being recommended. The goal of this pilot study was to evaluate preliminarily the capabilities of 3D MRI using ultra-short echo time for lung nodule volumetry, as it would provide a radiation-free modality for this task. Material and Methods: Artificial nodules were manufactured out of Agar and measured using an ultra-short echo time MRI sequence. CT data were also acquired as a reference. Image segmentation was carried out using an algorithm based on signal intensity thresholding (SIT). For comparison purposes, we also performed manual slice by slice segmentation. Volumes obtained with MRI and CT were compared. Finally, the volumetry of a lung nodule was evaluated in one human subject in comparison with CT. Results: Using the SIT technique, minimal bias was observed between CT and MRI across the entire range of volumes (2%) with limits of agreement below 14%. Comparison of manually segmented MRI and CT resulted in a larger bias (8%) and wider limits of agreement (−23% to 40%). In vivo, nodule volume differed of <16% between modalities with the SIT technique. Conclusion: This pilot study showed very good concordance between CT and UTE-MRI to quantify lung nodule volumes, in both a phantom and human setting. Our results enhance the potential of MRI to quantify pulmonary nodule volume with similar performance to CT.
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spelling pubmed-63792852019-02-26 MR Volumetry of Lung Nodules: A Pilot Study Delacoste, Jean Dunet, Vincent Dournes, Gael Lovis, Alban Rohner, Chantal Elandoy, Christel Simons, Julien Long, Olivier Piccini, Davide Stuber, Matthias Prior, John O. Nicod, Laurent Beigelman-Aubry, Catherine Front Med (Lausanne) Medicine Introduction: Computed tomography (CT) is currently the reference modality for the detection and follow-up of pulmonary nodules. While 2D measurements are commonly used in clinical practice to assess growth, increasingly 3D volume measurements are being recommended. The goal of this pilot study was to evaluate preliminarily the capabilities of 3D MRI using ultra-short echo time for lung nodule volumetry, as it would provide a radiation-free modality for this task. Material and Methods: Artificial nodules were manufactured out of Agar and measured using an ultra-short echo time MRI sequence. CT data were also acquired as a reference. Image segmentation was carried out using an algorithm based on signal intensity thresholding (SIT). For comparison purposes, we also performed manual slice by slice segmentation. Volumes obtained with MRI and CT were compared. Finally, the volumetry of a lung nodule was evaluated in one human subject in comparison with CT. Results: Using the SIT technique, minimal bias was observed between CT and MRI across the entire range of volumes (2%) with limits of agreement below 14%. Comparison of manually segmented MRI and CT resulted in a larger bias (8%) and wider limits of agreement (−23% to 40%). In vivo, nodule volume differed of <16% between modalities with the SIT technique. Conclusion: This pilot study showed very good concordance between CT and UTE-MRI to quantify lung nodule volumes, in both a phantom and human setting. Our results enhance the potential of MRI to quantify pulmonary nodule volume with similar performance to CT. Frontiers Media S.A. 2019-02-12 /pmc/articles/PMC6379285/ /pubmed/30809522 http://dx.doi.org/10.3389/fmed.2019.00018 Text en Copyright © 2019 Delacoste, Dunet, Dournes, Lovis, Rohner, Elandoy, Simons, Long, Piccini, Stuber, Prior, Nicod and Beigelman-Aubry. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Delacoste, Jean
Dunet, Vincent
Dournes, Gael
Lovis, Alban
Rohner, Chantal
Elandoy, Christel
Simons, Julien
Long, Olivier
Piccini, Davide
Stuber, Matthias
Prior, John O.
Nicod, Laurent
Beigelman-Aubry, Catherine
MR Volumetry of Lung Nodules: A Pilot Study
title MR Volumetry of Lung Nodules: A Pilot Study
title_full MR Volumetry of Lung Nodules: A Pilot Study
title_fullStr MR Volumetry of Lung Nodules: A Pilot Study
title_full_unstemmed MR Volumetry of Lung Nodules: A Pilot Study
title_short MR Volumetry of Lung Nodules: A Pilot Study
title_sort mr volumetry of lung nodules: a pilot study
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379285/
https://www.ncbi.nlm.nih.gov/pubmed/30809522
http://dx.doi.org/10.3389/fmed.2019.00018
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