Cargando…
IL-26, a Cytokine With Roles in Extracellular DNA-Induced Inflammation and Microbial Defense
Interleukin 26 (IL-26) is the most recently identified member of the IL-20 cytokine subfamily, and is a novel mediator of inflammation overexpressed in activated or transformed T cells. Novel properties have recently been assigned to IL-26, owing to its non-conventional cationic, and amphipathic fea...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379347/ https://www.ncbi.nlm.nih.gov/pubmed/30809226 http://dx.doi.org/10.3389/fimmu.2019.00204 |
_version_ | 1783396063082708992 |
---|---|
author | Larochette, Vincent Miot, Charline Poli, Caroline Beaumont, Elodie Roingeard, Philippe Fickenscher, Helmut Jeannin, Pascale Delneste, Yves |
author_facet | Larochette, Vincent Miot, Charline Poli, Caroline Beaumont, Elodie Roingeard, Philippe Fickenscher, Helmut Jeannin, Pascale Delneste, Yves |
author_sort | Larochette, Vincent |
collection | PubMed |
description | Interleukin 26 (IL-26) is the most recently identified member of the IL-20 cytokine subfamily, and is a novel mediator of inflammation overexpressed in activated or transformed T cells. Novel properties have recently been assigned to IL-26, owing to its non-conventional cationic, and amphipathic features. IL-26 binds to DNA released from damaged cells and, as a carrier molecule for extracellular DNA, links DNA to inflammation. This observation suggests that IL-26 may act both as a driver and an effector of inflammation, leading to the establishment of a deleterious amplification loop and, ultimately, sustained inflammation. Thus, IL-26 emerges as an important mediator in local immunity/inflammation. The dysregulated expression and extracellular DNA carrier capacity of IL-26 may have profound consequences for the chronicity of inflammation. IL-26 also exhibits direct antimicrobial properties. This review summarizes recent advances on the biology of IL-26 and discusses its roles as a novel kinocidin. |
format | Online Article Text |
id | pubmed-6379347 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-63793472019-02-26 IL-26, a Cytokine With Roles in Extracellular DNA-Induced Inflammation and Microbial Defense Larochette, Vincent Miot, Charline Poli, Caroline Beaumont, Elodie Roingeard, Philippe Fickenscher, Helmut Jeannin, Pascale Delneste, Yves Front Immunol Immunology Interleukin 26 (IL-26) is the most recently identified member of the IL-20 cytokine subfamily, and is a novel mediator of inflammation overexpressed in activated or transformed T cells. Novel properties have recently been assigned to IL-26, owing to its non-conventional cationic, and amphipathic features. IL-26 binds to DNA released from damaged cells and, as a carrier molecule for extracellular DNA, links DNA to inflammation. This observation suggests that IL-26 may act both as a driver and an effector of inflammation, leading to the establishment of a deleterious amplification loop and, ultimately, sustained inflammation. Thus, IL-26 emerges as an important mediator in local immunity/inflammation. The dysregulated expression and extracellular DNA carrier capacity of IL-26 may have profound consequences for the chronicity of inflammation. IL-26 also exhibits direct antimicrobial properties. This review summarizes recent advances on the biology of IL-26 and discusses its roles as a novel kinocidin. Frontiers Media S.A. 2019-02-12 /pmc/articles/PMC6379347/ /pubmed/30809226 http://dx.doi.org/10.3389/fimmu.2019.00204 Text en Copyright © 2019 Larochette, Miot, Poli, Beaumont, Roingeard, Fickenscher, Jeannin and Delneste. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Larochette, Vincent Miot, Charline Poli, Caroline Beaumont, Elodie Roingeard, Philippe Fickenscher, Helmut Jeannin, Pascale Delneste, Yves IL-26, a Cytokine With Roles in Extracellular DNA-Induced Inflammation and Microbial Defense |
title | IL-26, a Cytokine With Roles in Extracellular DNA-Induced Inflammation and Microbial Defense |
title_full | IL-26, a Cytokine With Roles in Extracellular DNA-Induced Inflammation and Microbial Defense |
title_fullStr | IL-26, a Cytokine With Roles in Extracellular DNA-Induced Inflammation and Microbial Defense |
title_full_unstemmed | IL-26, a Cytokine With Roles in Extracellular DNA-Induced Inflammation and Microbial Defense |
title_short | IL-26, a Cytokine With Roles in Extracellular DNA-Induced Inflammation and Microbial Defense |
title_sort | il-26, a cytokine with roles in extracellular dna-induced inflammation and microbial defense |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379347/ https://www.ncbi.nlm.nih.gov/pubmed/30809226 http://dx.doi.org/10.3389/fimmu.2019.00204 |
work_keys_str_mv | AT larochettevincent il26acytokinewithrolesinextracellulardnainducedinflammationandmicrobialdefense AT miotcharline il26acytokinewithrolesinextracellulardnainducedinflammationandmicrobialdefense AT policaroline il26acytokinewithrolesinextracellulardnainducedinflammationandmicrobialdefense AT beaumontelodie il26acytokinewithrolesinextracellulardnainducedinflammationandmicrobialdefense AT roingeardphilippe il26acytokinewithrolesinextracellulardnainducedinflammationandmicrobialdefense AT fickenscherhelmut il26acytokinewithrolesinextracellulardnainducedinflammationandmicrobialdefense AT jeanninpascale il26acytokinewithrolesinextracellulardnainducedinflammationandmicrobialdefense AT delnesteyves il26acytokinewithrolesinextracellulardnainducedinflammationandmicrobialdefense |