HIV-1 vaccination by needle-free oral injection induces strong mucosal immunity and protects against SHIV challenge

The oral mucosa is an attractive site for mucosal vaccination, however the thick squamous epithelium limits antigen uptake. Here we utilize a modified needle-free injector to deliver immunizations to the sublingual and buccal (SL/B) tissue of rhesus macaques. Needle-free SL/B vaccination with modifi...

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Detalles Bibliográficos
Autores principales: Jones, Andrew T., Shen, Xiaoying, Walter, Korey L., LaBranche, Celia C., Wyatt, Linda S., Tomaras, Georgia D., Montefiori, David C., Moss, Bernard, Barouch, Dan H., Clements, John D., Kozlowski, Pamela A., Varadarajan, Raghavan, Amara, Rama Rao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379385/
https://www.ncbi.nlm.nih.gov/pubmed/30778066
http://dx.doi.org/10.1038/s41467-019-08739-4

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