Leukadherin-1-Mediated Activation of CD11b Inhibits LPS-Induced Pro-inflammatory Response in Macrophages and Protects Mice Against Endotoxic Shock by Blocking LPS-TLR4 Interaction

Dysregulation of macrophage has been demonstrated to contribute to aberrant immune responses and inflammatory diseases. CD11b, expressed on macrophages, plays a critical role in regulating pathogen recognition, phagocytosis, and cell survival. In the present study, we explored the effect of leukadhe...

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Detalles Bibliográficos
Autores principales: Yao, Xiaoying, Dong, Guanjun, Zhu, Yuzhen, Yan, Fenglian, Zhang, Hui, Ma, Qun, Fu, Xingqin, Li, Xuehui, Zhang, QingQing, Zhang, Junfeng, Shi, Hui, Ning, Zhaochen, Dai, Jun, Li, Zhihua, Li, Chunxia, Wang, Bo, Ming, Jiankuo, Yang, Yonghong, Hong, Feng, Meng, Xiangzhi, Xiong, Huabao, Si, Chuanping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379471/
https://www.ncbi.nlm.nih.gov/pubmed/30809230
http://dx.doi.org/10.3389/fimmu.2019.00215

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