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Enhancement of ascomycin production via a combination of atmospheric and room temperature plasma mutagenesis in Streptomyces hygroscopicus and medium optimization

Ascomycin, a key intermediate for chemical synthesis of immunosuppressive drug pimecrolimus, is produced by Streptomyces hygroscopicus var. ascomyceticus. In order to improve the strain production, the original S. hygroscopicus ATCC 14891 strain was treated here with atmospheric and room temperature...

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Detalles Bibliográficos
Autores principales:	Yu, Zhituo, Shen, Xiaofang, Wu, Yuanjie, Yang, Songbai, Ju, Dianwen, Chen, Shaoxin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2019
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379505/ https://www.ncbi.nlm.nih.gov/pubmed/30778695 http://dx.doi.org/10.1186/s13568-019-0749-x

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