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Abnormalities of white matter microstructure in unmedicated patients with obsessive–compulsive disorder: Changes after cognitive behavioral therapy

BACKGROUND: Cognitive behavioral therapy (CBT) is an effective treatment for Obsessive–compulsive disorder (OCD). Structural and functional white matter defects may suggest a vital neurobiological basis of OCD. However, the effects of CBT on white matter in OCD remain unknown. OBJECTIVE: The aim was...

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Autores principales: Zhong, ZhaoXi, Yang, XiangYun, Cao, RuiXiang, Li, Ping, Li, ZhanJiang, Lv, LuXian, Zhang, Dai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379596/
https://www.ncbi.nlm.nih.gov/pubmed/30623612
http://dx.doi.org/10.1002/brb3.1201
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author Zhong, ZhaoXi
Yang, XiangYun
Cao, RuiXiang
Li, Ping
Li, ZhanJiang
Lv, LuXian
Zhang, Dai
author_facet Zhong, ZhaoXi
Yang, XiangYun
Cao, RuiXiang
Li, Ping
Li, ZhanJiang
Lv, LuXian
Zhang, Dai
author_sort Zhong, ZhaoXi
collection PubMed
description BACKGROUND: Cognitive behavioral therapy (CBT) is an effective treatment for Obsessive–compulsive disorder (OCD). Structural and functional white matter defects may suggest a vital neurobiological basis of OCD. However, the effects of CBT on white matter in OCD remain unknown. OBJECTIVE: The aim was to investigate white matter changes and the effect of CBT on white matter in OCD patients. METHODS: Fractional anisotropy (FA) maps were acquired using DTI. Participants included 85 patients with OCD and 90 healthy controls. VBM was then performed to detect regions with significant group differences. RESULTS: Obsessive–compulsive disorder patients exhibited significantly reduced FA values in bilateral OFC, right cerebellum, and left SPG, while higher FA values were observed in right PUT compared with healthy controls. Following CBT, OCD patients showed higher FA values in right MFG, left OFC, right cerebellum, and left MTG, and decreased FA values in right PUT in comparison with pretreatment. Furthermore, FA values in the left OFC of patients were significantly positively correlated with the Y‐BOCS and its associated Compulsions subscale, and FA values in the right PUT were positively correlated with Compulsions subscale. In addition, the percentage change in FA values in left MTG was positively correlated with the percentage reduction in Compulsions subscale, while the percentage change in FA values in left OFC and right PUT was negatively correlated with the percentage reductions in Obsessive and Compulsions subscale, respectively. CONCLUSIONS: Our findings demonstrate the abnormalities of white matter microstructure in unmedicated patients with OCD. These abnormalities may be partly reversed by CBT.
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spelling pubmed-63795962019-02-28 Abnormalities of white matter microstructure in unmedicated patients with obsessive–compulsive disorder: Changes after cognitive behavioral therapy Zhong, ZhaoXi Yang, XiangYun Cao, RuiXiang Li, Ping Li, ZhanJiang Lv, LuXian Zhang, Dai Brain Behav Original Research BACKGROUND: Cognitive behavioral therapy (CBT) is an effective treatment for Obsessive–compulsive disorder (OCD). Structural and functional white matter defects may suggest a vital neurobiological basis of OCD. However, the effects of CBT on white matter in OCD remain unknown. OBJECTIVE: The aim was to investigate white matter changes and the effect of CBT on white matter in OCD patients. METHODS: Fractional anisotropy (FA) maps were acquired using DTI. Participants included 85 patients with OCD and 90 healthy controls. VBM was then performed to detect regions with significant group differences. RESULTS: Obsessive–compulsive disorder patients exhibited significantly reduced FA values in bilateral OFC, right cerebellum, and left SPG, while higher FA values were observed in right PUT compared with healthy controls. Following CBT, OCD patients showed higher FA values in right MFG, left OFC, right cerebellum, and left MTG, and decreased FA values in right PUT in comparison with pretreatment. Furthermore, FA values in the left OFC of patients were significantly positively correlated with the Y‐BOCS and its associated Compulsions subscale, and FA values in the right PUT were positively correlated with Compulsions subscale. In addition, the percentage change in FA values in left MTG was positively correlated with the percentage reduction in Compulsions subscale, while the percentage change in FA values in left OFC and right PUT was negatively correlated with the percentage reductions in Obsessive and Compulsions subscale, respectively. CONCLUSIONS: Our findings demonstrate the abnormalities of white matter microstructure in unmedicated patients with OCD. These abnormalities may be partly reversed by CBT. John Wiley and Sons Inc. 2019-01-09 /pmc/articles/PMC6379596/ /pubmed/30623612 http://dx.doi.org/10.1002/brb3.1201 Text en © 2019 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Zhong, ZhaoXi
Yang, XiangYun
Cao, RuiXiang
Li, Ping
Li, ZhanJiang
Lv, LuXian
Zhang, Dai
Abnormalities of white matter microstructure in unmedicated patients with obsessive–compulsive disorder: Changes after cognitive behavioral therapy
title Abnormalities of white matter microstructure in unmedicated patients with obsessive–compulsive disorder: Changes after cognitive behavioral therapy
title_full Abnormalities of white matter microstructure in unmedicated patients with obsessive–compulsive disorder: Changes after cognitive behavioral therapy
title_fullStr Abnormalities of white matter microstructure in unmedicated patients with obsessive–compulsive disorder: Changes after cognitive behavioral therapy
title_full_unstemmed Abnormalities of white matter microstructure in unmedicated patients with obsessive–compulsive disorder: Changes after cognitive behavioral therapy
title_short Abnormalities of white matter microstructure in unmedicated patients with obsessive–compulsive disorder: Changes after cognitive behavioral therapy
title_sort abnormalities of white matter microstructure in unmedicated patients with obsessive–compulsive disorder: changes after cognitive behavioral therapy
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379596/
https://www.ncbi.nlm.nih.gov/pubmed/30623612
http://dx.doi.org/10.1002/brb3.1201
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