Serological response to influenza vaccination among adults hospitalized with community‐acquired pneumonia

Ninety‐five adults enrolled in the Etiology of Pneumonia in the Community study with negative admission influenza polymerase chain reaction (PCR) tests received influenza vaccination during hospitalization. Acute and convalescent influenza serology was performed. After vaccination, seropositive (≥1:...

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Detalles Bibliográficos
Autores principales: Pratt, Caroline Quinn, Zhu, Yuwei, Grijalva, Carlos G., Wunderink, Richard G., Mark Courtney, D., Waterer, Grant, Levine, Min Z, Jefferson, Stacie, Self, Wesley H., Williams, Derek J., Finelli, Lynn, Bramley, Anna M., Edwards, Kathryn M., Jain, Seema, Anderson, Evan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Short Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379631/
https://www.ncbi.nlm.nih.gov/pubmed/30485702
http://dx.doi.org/10.1111/irv.12622
Descripción
Sumario:Ninety‐five adults enrolled in the Etiology of Pneumonia in the Community study with negative admission influenza polymerase chain reaction (PCR) tests received influenza vaccination during hospitalization. Acute and convalescent influenza serology was performed. After vaccination, seropositive (≥1:40) hemagglutination antibody titers (HAI) were achieved in 55% to influenza A(H1N1)pdm09, 58% to influenza A(H3N2), 77% to influenza B (Victoria), and 74% to influenza B (Yamagata) viruses. Sixty‐six (69%) patients seroconverted (≥4‐fold HAI rise) to ≥1 strain. Failure to seroconvert was associated with diabetes, bacterial detection, baseline seropositive titers for influenza B (Yamagata), and influenza vaccination in the previous season.

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