Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex

Aberrant isoform expression of chromatin-associated proteins can induce epigenetic programs related to disease. The MDS1 and EVI1 complex locus (MECOM) encodes PRDM3, a protein with an N-terminal PR-SET domain, as well as a shorter isoform, EVI1, lacking the N-terminus containing the PR-SET domain (...

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Detalles Bibliográficos
Autores principales: Ivanochko, Danton, Halabelian, Levon, Henderson, Elizabeth, Savitsky, Pavel, Jain, Harshika, Marcon, Edyta, Duan, Shili, Hutchinson, Ashley, Seitova, Alma, Barsyte-Lovejoy, Dalia, Filippakopoulos, Panagis, Greenblatt, Jack, Lima-Fernandes, Evelyne, Arrowsmith, Cheryl H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379669/
https://www.ncbi.nlm.nih.gov/pubmed/30462309
http://dx.doi.org/10.1093/nar/gky1192

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