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An ultra-high affinity ligand of HIV-1 TAR reveals the RNA structure recognized by P-TEFb
The HIV-1 trans-activator protein Tat binds the trans-activation response element (TAR) to facilitate recruitment of the super elongation complex (SEC) to enhance transcription of the integrated pro-viral genome. The Tat–TAR interaction is critical for viral replication and the emergence of the viru...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379670/ https://www.ncbi.nlm.nih.gov/pubmed/30481318 http://dx.doi.org/10.1093/nar/gky1197 |