An ultra-high affinity ligand of HIV-1 TAR reveals the RNA structure recognized by P-TEFb

The HIV-1 trans-activator protein Tat binds the trans-activation response element (TAR) to facilitate recruitment of the super elongation complex (SEC) to enhance transcription of the integrated pro-viral genome. The Tat–TAR interaction is critical for viral replication and the emergence of the viru...

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Detalles Bibliográficos
Autores principales: Shortridge, Matthew D, Wille, Paul T, Jones, Alisha N, Davidson, Amy, Bogdanovic, Jasmina, Arts, Eric, Karn, Jonathan, Robinson, John A, Varani, Gabriele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379670/
https://www.ncbi.nlm.nih.gov/pubmed/30481318
http://dx.doi.org/10.1093/nar/gky1197

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