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Structure and two-metal mechanism of fungal tRNA ligase

Fungal tRNA ligase (Trl1) is an essential enzyme that repairs RNA breaks with 2′,3′-cyclic-PO(4) and 5′-OH ends inflicted during tRNA splicing and non-canonical mRNA splicing in the fungal unfolded protein response. Trl1 is composed of C-terminal cyclic phosphodiesterase (CPD) and central GTP-depend...

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Detalles Bibliográficos
Autores principales:	Banerjee, Ankan, Ghosh, Shreya, Goldgur, Yehuda, Shuman, Stewart
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379707/ https://www.ncbi.nlm.nih.gov/pubmed/30590734 http://dx.doi.org/10.1093/nar/gky1275

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