Identification of patients with pancreatic adenocarcinoma due to inheritable mutation: Challenges of daily clinical practice

BACKGROUND: Identification of germ-line mutations in pancreatic ductal adenocarcinoma (PDAC) could impact on patient/family. AIM: To assess the referral pathways for genetic consultations in PDAC. METHODS: Electronic records of PDAC patients were reviewed retrospectively. Patients eligible for genet...

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Autores principales: Fulton, Alexander JP, Lamarca, Angela, Nuttall, Christina, McCallum, Lynne, Pihlak, Rille, O’Reilly, Derek, Lalloo, Fiona, McNamara, Mairéad G, Hubner, Richard A, Clancy, Tara, Valle, Juan W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2019
Materias:
Retrospective Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379756/
https://www.ncbi.nlm.nih.gov/pubmed/30788038
http://dx.doi.org/10.4251/wjgo.v11.i2.102
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author Fulton, Alexander JP
Lamarca, Angela
Nuttall, Christina
McCallum, Lynne
Pihlak, Rille
O’Reilly, Derek
Lalloo, Fiona
McNamara, Mairéad G
Hubner, Richard A
Clancy, Tara
Valle, Juan W
author_facet Fulton, Alexander JP
Lamarca, Angela
Nuttall, Christina
McCallum, Lynne
Pihlak, Rille
O’Reilly, Derek
Lalloo, Fiona
McNamara, Mairéad G
Hubner, Richard A
Clancy, Tara
Valle, Juan W
author_sort Fulton, Alexander JP
collection PubMed
description BACKGROUND: Identification of germ-line mutations in pancreatic ductal adenocarcinoma (PDAC) could impact on patient/family. AIM: To assess the referral pathways for genetic consultations in PDAC. METHODS: Electronic records of PDAC patients were reviewed retrospectively. Patients eligible for genetic consultation referral were identified following the European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer (EUROPAC) criteria. RESULTS: Four-hundred patients were eligible. Of 113 patients (28.3%) meeting EUROPAC criteria, 8.8% were referred for genetic opinion. Germ-line mutations were identified in 0.75% of the whole population. CONCLUSION: Earlier referrals and increased awareness may be able to overcome the low rate of successful genetic appointments.
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spelling pubmed-63797562019-02-20 Identification of patients with pancreatic adenocarcinoma due to inheritable mutation: Challenges of daily clinical practice Fulton, Alexander JP Lamarca, Angela Nuttall, Christina McCallum, Lynne Pihlak, Rille O’Reilly, Derek Lalloo, Fiona McNamara, Mairéad G Hubner, Richard A Clancy, Tara Valle, Juan W World J Gastrointest Oncol Retrospective Study BACKGROUND: Identification of germ-line mutations in pancreatic ductal adenocarcinoma (PDAC) could impact on patient/family. AIM: To assess the referral pathways for genetic consultations in PDAC. METHODS: Electronic records of PDAC patients were reviewed retrospectively. Patients eligible for genetic consultation referral were identified following the European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer (EUROPAC) criteria. RESULTS: Four-hundred patients were eligible. Of 113 patients (28.3%) meeting EUROPAC criteria, 8.8% were referred for genetic opinion. Germ-line mutations were identified in 0.75% of the whole population. CONCLUSION: Earlier referrals and increased awareness may be able to overcome the low rate of successful genetic appointments. Baishideng Publishing Group Inc 2019-02-15 2019-02-15 /pmc/articles/PMC6379756/ /pubmed/30788038 http://dx.doi.org/10.4251/wjgo.v11.i2.102 Text en ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Retrospective Study
Fulton, Alexander JP
Lamarca, Angela
Nuttall, Christina
McCallum, Lynne
Pihlak, Rille
O’Reilly, Derek
Lalloo, Fiona
McNamara, Mairéad G
Hubner, Richard A
Clancy, Tara
Valle, Juan W
Identification of patients with pancreatic adenocarcinoma due to inheritable mutation: Challenges of daily clinical practice
title Identification of patients with pancreatic adenocarcinoma due to inheritable mutation: Challenges of daily clinical practice
title_full Identification of patients with pancreatic adenocarcinoma due to inheritable mutation: Challenges of daily clinical practice
title_fullStr Identification of patients with pancreatic adenocarcinoma due to inheritable mutation: Challenges of daily clinical practice
title_full_unstemmed Identification of patients with pancreatic adenocarcinoma due to inheritable mutation: Challenges of daily clinical practice
title_short Identification of patients with pancreatic adenocarcinoma due to inheritable mutation: Challenges of daily clinical practice
title_sort identification of patients with pancreatic adenocarcinoma due to inheritable mutation: challenges of daily clinical practice
topic Retrospective Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379756/
https://www.ncbi.nlm.nih.gov/pubmed/30788038
http://dx.doi.org/10.4251/wjgo.v11.i2.102
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