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Effect of Hepatitis B Virus (HBV) Infection on Lipid Profile in Ghanaian Patients

BACKGROUND: Worldwide, approximately 257 million people have chronic hepatitis B virus (HBV) infection, with the highest infection rates recorded in Africa and Asia. Although HBV infection has been associated with dyslipidemia, which may lead to death via liver related complications, the effect of t...

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Autores principales: Quaye, Osbourne, Amuzu, Benjamin Godfried, Adadey, Samuel Mawuli, Tagoe, Emmanuel Ayitey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379792/
https://www.ncbi.nlm.nih.gov/pubmed/30799916
http://dx.doi.org/10.1177/1178122X19827606
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author Quaye, Osbourne
Amuzu, Benjamin Godfried
Adadey, Samuel Mawuli
Tagoe, Emmanuel Ayitey
author_facet Quaye, Osbourne
Amuzu, Benjamin Godfried
Adadey, Samuel Mawuli
Tagoe, Emmanuel Ayitey
author_sort Quaye, Osbourne
collection PubMed
description BACKGROUND: Worldwide, approximately 257 million people have chronic hepatitis B virus (HBV) infection, with the highest infection rates recorded in Africa and Asia. Although HBV infection has been associated with dyslipidemia, which may lead to death via liver related complications, the effect of the virus on the lipid profile of patients remain unclear. This study was designed to evaluate the effect of chronic hepatitis B virus infection on lipid profile of sero-positive individuals from Ghana. METHODS: Blood samples were collected from chronic HBV infected patients who were recruited from the Korle-Bu Teaching Hospital, Accra, and HBV sero-negative healthy volunteers who were used as controls. Demographic and clinical data were obtained using a structured questionnaire. Blood pressure and body mass index were determined, and HBV profile markers and lipid profiles of the patients were determined using a commercially available kit and a chemistry analyzer, respectively. RESULTS: Triglycerides, low density lipoproteins (LDL), high density lipoproteins (HDL), very low density lipoproteins (VLDL), and total cholesterol were used as indices of lipid metabolism disorder. Body mass index and diastolic blood pressures were significantly elevated in patients compared to healthy volunteers. CONCLUSION: The observed high total cholesterol and LDL, with a significantly lower HDL levels compared to healthy controls suggest an increased cardiovascular disease risk index in the patients. There is therefore the need to regularly monitor HBV infected patients for signs of cardiovascular diseases.
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spelling pubmed-63797922019-02-22 Effect of Hepatitis B Virus (HBV) Infection on Lipid Profile in Ghanaian Patients Quaye, Osbourne Amuzu, Benjamin Godfried Adadey, Samuel Mawuli Tagoe, Emmanuel Ayitey Virology (Auckl) Original Research BACKGROUND: Worldwide, approximately 257 million people have chronic hepatitis B virus (HBV) infection, with the highest infection rates recorded in Africa and Asia. Although HBV infection has been associated with dyslipidemia, which may lead to death via liver related complications, the effect of the virus on the lipid profile of patients remain unclear. This study was designed to evaluate the effect of chronic hepatitis B virus infection on lipid profile of sero-positive individuals from Ghana. METHODS: Blood samples were collected from chronic HBV infected patients who were recruited from the Korle-Bu Teaching Hospital, Accra, and HBV sero-negative healthy volunteers who were used as controls. Demographic and clinical data were obtained using a structured questionnaire. Blood pressure and body mass index were determined, and HBV profile markers and lipid profiles of the patients were determined using a commercially available kit and a chemistry analyzer, respectively. RESULTS: Triglycerides, low density lipoproteins (LDL), high density lipoproteins (HDL), very low density lipoproteins (VLDL), and total cholesterol were used as indices of lipid metabolism disorder. Body mass index and diastolic blood pressures were significantly elevated in patients compared to healthy volunteers. CONCLUSION: The observed high total cholesterol and LDL, with a significantly lower HDL levels compared to healthy controls suggest an increased cardiovascular disease risk index in the patients. There is therefore the need to regularly monitor HBV infected patients for signs of cardiovascular diseases. SAGE Publications 2019-02-18 /pmc/articles/PMC6379792/ /pubmed/30799916 http://dx.doi.org/10.1177/1178122X19827606 Text en © The Author(s) 2019 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research
Quaye, Osbourne
Amuzu, Benjamin Godfried
Adadey, Samuel Mawuli
Tagoe, Emmanuel Ayitey
Effect of Hepatitis B Virus (HBV) Infection on Lipid Profile in Ghanaian Patients
title Effect of Hepatitis B Virus (HBV) Infection on Lipid Profile in Ghanaian Patients
title_full Effect of Hepatitis B Virus (HBV) Infection on Lipid Profile in Ghanaian Patients
title_fullStr Effect of Hepatitis B Virus (HBV) Infection on Lipid Profile in Ghanaian Patients
title_full_unstemmed Effect of Hepatitis B Virus (HBV) Infection on Lipid Profile in Ghanaian Patients
title_short Effect of Hepatitis B Virus (HBV) Infection on Lipid Profile in Ghanaian Patients
title_sort effect of hepatitis b virus (hbv) infection on lipid profile in ghanaian patients
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379792/
https://www.ncbi.nlm.nih.gov/pubmed/30799916
http://dx.doi.org/10.1177/1178122X19827606
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