Insertion of N-Terminal Hinge Glycosylation Enhances Interactions of the Fc Region of Human IgG1 Monomers with Glycan-Dependent Receptors and Blocks Hemagglutination by the Influenza Virus

In therapeutic applications in which the Fc of IgG is critically important, the receptor binding and functional properties of the Fc are lost after deglycosylation or removal of the unique Asn(297) N-X-(T/S) sequon. A population of Fcs bearing sialylated glycans has been identified as contributing t...

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Detalles Bibliográficos
Autores principales: Blundell, Patricia A., Lu, Dongli, Wilkinson, Mark, Dell, Anne, Haslam, Stuart, Pleass, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAI 2019
Materias:
Molecular and Structural Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379808/
https://www.ncbi.nlm.nih.gov/pubmed/30683699
http://dx.doi.org/10.4049/jimmunol.1801337

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379808/
https://www.ncbi.nlm.nih.gov/pubmed/30683699
http://dx.doi.org/10.4049/jimmunol.1801337

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