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Efficiency of Multiparticulate Delivery Systems Loaded with Flufenamic Acid Designed for Burn Wound Healing Applications
Burns are soft tissue injuries that require particular care for wound healing. Current tissue engineering approaches are aimed at identifying the most efficient treatment combinations to restore the tissue properties and function by using adapted scaffolds or delivery platforms for tissue repair and...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379844/ https://www.ncbi.nlm.nih.gov/pubmed/30868078 http://dx.doi.org/10.1155/2019/4513108 |
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author | Dinescu, Sorina Ignat, Simona Rebeca Lazar, Andreea Daniela Marin, Ștefania Danilă, Elena Marin, Maria M. Udeanu, Denisa Ioana Ghica, Mihaela Violeta Albu-Kaya, Mădălina G. Costache, Marieta |
author_facet | Dinescu, Sorina Ignat, Simona Rebeca Lazar, Andreea Daniela Marin, Ștefania Danilă, Elena Marin, Maria M. Udeanu, Denisa Ioana Ghica, Mihaela Violeta Albu-Kaya, Mădălina G. Costache, Marieta |
author_sort | Dinescu, Sorina |
collection | PubMed |
description | Burns are soft tissue injuries that require particular care for wound healing. Current tissue engineering approaches are aimed at identifying the most efficient treatment combinations to restore the tissue properties and function by using adapted scaffolds or delivery platforms for tissue repair and regeneration by triggering molecules. To reduce the inflammation associated with skin burns, the addition of an anti-inflammatory factor in these scaffolds would greatly increase the quality of the therapy. Therefore, this study is aimed at obtaining and validating a novel multiparticulate system based on a collagen matrix with controlled delivery of flufenamic acid anti-inflammatory drug for burn wound healing applications. In this work, we have characterized the properties and biocompatibility of these multiparticulate drug delivery systems (MDDS) and we have demonstrated their efficiency against burns and soft tissue lesions, particularly when the drug was microencapsulated, and thus with a controlled release. This study contributes to the advancement in therapy of burns and burn wound healing applications. |
format | Online Article Text |
id | pubmed-6379844 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-63798442019-03-13 Efficiency of Multiparticulate Delivery Systems Loaded with Flufenamic Acid Designed for Burn Wound Healing Applications Dinescu, Sorina Ignat, Simona Rebeca Lazar, Andreea Daniela Marin, Ștefania Danilă, Elena Marin, Maria M. Udeanu, Denisa Ioana Ghica, Mihaela Violeta Albu-Kaya, Mădălina G. Costache, Marieta J Immunol Res Research Article Burns are soft tissue injuries that require particular care for wound healing. Current tissue engineering approaches are aimed at identifying the most efficient treatment combinations to restore the tissue properties and function by using adapted scaffolds or delivery platforms for tissue repair and regeneration by triggering molecules. To reduce the inflammation associated with skin burns, the addition of an anti-inflammatory factor in these scaffolds would greatly increase the quality of the therapy. Therefore, this study is aimed at obtaining and validating a novel multiparticulate system based on a collagen matrix with controlled delivery of flufenamic acid anti-inflammatory drug for burn wound healing applications. In this work, we have characterized the properties and biocompatibility of these multiparticulate drug delivery systems (MDDS) and we have demonstrated their efficiency against burns and soft tissue lesions, particularly when the drug was microencapsulated, and thus with a controlled release. This study contributes to the advancement in therapy of burns and burn wound healing applications. Hindawi 2019-02-05 /pmc/articles/PMC6379844/ /pubmed/30868078 http://dx.doi.org/10.1155/2019/4513108 Text en Copyright © 2019 Sorina Dinescu et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Dinescu, Sorina Ignat, Simona Rebeca Lazar, Andreea Daniela Marin, Ștefania Danilă, Elena Marin, Maria M. Udeanu, Denisa Ioana Ghica, Mihaela Violeta Albu-Kaya, Mădălina G. Costache, Marieta Efficiency of Multiparticulate Delivery Systems Loaded with Flufenamic Acid Designed for Burn Wound Healing Applications |
title | Efficiency of Multiparticulate Delivery Systems Loaded with Flufenamic Acid Designed for Burn Wound Healing Applications |
title_full | Efficiency of Multiparticulate Delivery Systems Loaded with Flufenamic Acid Designed for Burn Wound Healing Applications |
title_fullStr | Efficiency of Multiparticulate Delivery Systems Loaded with Flufenamic Acid Designed for Burn Wound Healing Applications |
title_full_unstemmed | Efficiency of Multiparticulate Delivery Systems Loaded with Flufenamic Acid Designed for Burn Wound Healing Applications |
title_short | Efficiency of Multiparticulate Delivery Systems Loaded with Flufenamic Acid Designed for Burn Wound Healing Applications |
title_sort | efficiency of multiparticulate delivery systems loaded with flufenamic acid designed for burn wound healing applications |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379844/ https://www.ncbi.nlm.nih.gov/pubmed/30868078 http://dx.doi.org/10.1155/2019/4513108 |
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