Transient Compound Treatment Induces a Multigenerational Reduction of Oxysterol-Binding Protein (OSBP) Levels and Prophylactic Antiviral Activity

[Image: see text] Oxysterol-binding protein (OSBP) is a lipid transport and regulatory protein required for the replication of Enterovirus genus viruses, which includes many significant human pathogens. Short-term exposure (i.e., 1–6 h) to a low dose (i.e., 1 nM) of the natural product compound OSW-...

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Detalles Bibliográficos
Autores principales: Roberts, Brett L., Severance, Zachary C., Bensen, Ryan C., Le, Anh T., Kothapalli, Naga Rama, Nuñez, Juan I., Ma, Hongyan, Wu, Si, Standke, Shawna J., Yang, Zhibo, Reddig, William J., Blewett, Earl L., Burgett, Anthony W. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379863/
https://www.ncbi.nlm.nih.gov/pubmed/30576108
http://dx.doi.org/10.1021/acschembio.8b00984

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