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Ocular outcomes and comorbidities in preterm infants enrolled for retinopathy of prematurity screening: A cohort study from western India

BACKGROUND: Retinopathy of prematurity (ROP) is emerging as an important cause of childhood blindness in middle-income countries such as India. Although blindness can be prevented in most cases with timely screening and treatment, certain ocular comorbidities can lead to visual impairment. We evalua...

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Autores principales: Kulkarni, Sucheta, Shah, Mukti, Dole, Kuldeep, Taras, Sudhir, Deshpande, Rahul, Deshpande, Madan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380145/
https://www.ncbi.nlm.nih.gov/pubmed/30787528
http://dx.doi.org/10.4103/ojo.OJO_221_2017
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author Kulkarni, Sucheta
Shah, Mukti
Dole, Kuldeep
Taras, Sudhir
Deshpande, Rahul
Deshpande, Madan
author_facet Kulkarni, Sucheta
Shah, Mukti
Dole, Kuldeep
Taras, Sudhir
Deshpande, Rahul
Deshpande, Madan
author_sort Kulkarni, Sucheta
collection PubMed
description BACKGROUND: Retinopathy of prematurity (ROP) is emerging as an important cause of childhood blindness in middle-income countries such as India. Although blindness can be prevented in most cases with timely screening and treatment, certain ocular comorbidities can lead to visual impairment. We evaluated and compared 1-year visual, refractive, and structural outcomes and comorbidities in three subsets of preterm infants enrolled for screening of ROP. SUBJECTS AND METHODS: Preterm children enrolled in the hospital's ROP screening program and with diagnosis of no ROP, mild ROP, or severe ROP were followed at 1 year of age to evaluate and compare visual, refractive, and structural outcomes as well as the presence of ocular comorbidities. Risk of poor outcome was calculated in children with mild and severe ROP reference population being children without ROP. RESULTS: Eyes with severe ROP were at highest risk of poor visual (risk ratio [RR]: 3.5, P < 0.001), refractive (RR: 45, P < 0.001), and structural (RR: 11, P = 0.006) outcome as well as ocular comorbidities (RR 11, P < 0.001). Eyes with mild ROP were at higher risk of myopia (RR: 11, P = 0.06) and ocular comorbidities (RR: 4, P = 0.04). Sixteen (16%) of the eyes without ROP developed poor visual outcome. CONCLUSION: Eyes with severe ROP are at highest risk of poor ocular outcomes and comorbidities and need a long-term follow-up. Eyes which do not develop ROP can have poor visual outcome and need to be assessed within the 1(st) year of life.
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spelling pubmed-63801452019-02-20 Ocular outcomes and comorbidities in preterm infants enrolled for retinopathy of prematurity screening: A cohort study from western India Kulkarni, Sucheta Shah, Mukti Dole, Kuldeep Taras, Sudhir Deshpande, Rahul Deshpande, Madan Oman J Ophthalmol Original Article BACKGROUND: Retinopathy of prematurity (ROP) is emerging as an important cause of childhood blindness in middle-income countries such as India. Although blindness can be prevented in most cases with timely screening and treatment, certain ocular comorbidities can lead to visual impairment. We evaluated and compared 1-year visual, refractive, and structural outcomes and comorbidities in three subsets of preterm infants enrolled for screening of ROP. SUBJECTS AND METHODS: Preterm children enrolled in the hospital's ROP screening program and with diagnosis of no ROP, mild ROP, or severe ROP were followed at 1 year of age to evaluate and compare visual, refractive, and structural outcomes as well as the presence of ocular comorbidities. Risk of poor outcome was calculated in children with mild and severe ROP reference population being children without ROP. RESULTS: Eyes with severe ROP were at highest risk of poor visual (risk ratio [RR]: 3.5, P < 0.001), refractive (RR: 45, P < 0.001), and structural (RR: 11, P = 0.006) outcome as well as ocular comorbidities (RR 11, P < 0.001). Eyes with mild ROP were at higher risk of myopia (RR: 11, P = 0.06) and ocular comorbidities (RR: 4, P = 0.04). Sixteen (16%) of the eyes without ROP developed poor visual outcome. CONCLUSION: Eyes with severe ROP are at highest risk of poor ocular outcomes and comorbidities and need a long-term follow-up. Eyes which do not develop ROP can have poor visual outcome and need to be assessed within the 1(st) year of life. Medknow Publications & Media Pvt Ltd 2019 /pmc/articles/PMC6380145/ /pubmed/30787528 http://dx.doi.org/10.4103/ojo.OJO_221_2017 Text en Copyright: © 2019 Oman Ophthalmic Society http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Kulkarni, Sucheta
Shah, Mukti
Dole, Kuldeep
Taras, Sudhir
Deshpande, Rahul
Deshpande, Madan
Ocular outcomes and comorbidities in preterm infants enrolled for retinopathy of prematurity screening: A cohort study from western India
title Ocular outcomes and comorbidities in preterm infants enrolled for retinopathy of prematurity screening: A cohort study from western India
title_full Ocular outcomes and comorbidities in preterm infants enrolled for retinopathy of prematurity screening: A cohort study from western India
title_fullStr Ocular outcomes and comorbidities in preterm infants enrolled for retinopathy of prematurity screening: A cohort study from western India
title_full_unstemmed Ocular outcomes and comorbidities in preterm infants enrolled for retinopathy of prematurity screening: A cohort study from western India
title_short Ocular outcomes and comorbidities in preterm infants enrolled for retinopathy of prematurity screening: A cohort study from western India
title_sort ocular outcomes and comorbidities in preterm infants enrolled for retinopathy of prematurity screening: a cohort study from western india
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380145/
https://www.ncbi.nlm.nih.gov/pubmed/30787528
http://dx.doi.org/10.4103/ojo.OJO_221_2017
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