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Rabs on the fly: Functions of Rab GTPases during development

The organization of intracellular transport processes is adapted specifically to different cell types, developmental stages, and physiologic requirements. Some protein traffic routes are universal to all cells and constitutively active, while other routes are cell-type specific, transient, and induc...

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Autores principales: Caviglia, Sara, Flores-Benitez, David, Lattner, Johanna, Luschnig, Stefan, Brankatschk, Marko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380344/
https://www.ncbi.nlm.nih.gov/pubmed/28118081
http://dx.doi.org/10.1080/21541248.2017.1279725
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author Caviglia, Sara
Flores-Benitez, David
Lattner, Johanna
Luschnig, Stefan
Brankatschk, Marko
author_facet Caviglia, Sara
Flores-Benitez, David
Lattner, Johanna
Luschnig, Stefan
Brankatschk, Marko
author_sort Caviglia, Sara
collection PubMed
description The organization of intracellular transport processes is adapted specifically to different cell types, developmental stages, and physiologic requirements. Some protein traffic routes are universal to all cells and constitutively active, while other routes are cell-type specific, transient, and induced under particular conditions only. Small GTPases of the Rab (Ras related in brain) subfamily are conserved across eukaryotes and regulate most intracellular transit pathways. The complete sets of Rab proteins have been identified in model organisms, and molecular principles underlying Rab functions have been uncovered. Rabs provide intracellular landmarks that define intracellular transport sequences. Nevertheless, it remains a challenge to systematically map the subcellular distribution of all Rabs and their functional interrelations. This task requires novel tools to precisely describe and manipulate the Rab machinery in vivo. Here we discuss recent findings about Rab roles during development and we consider novel approaches to investigate Rab functions in vivo.
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spelling pubmed-63803442019-02-25 Rabs on the fly: Functions of Rab GTPases during development Caviglia, Sara Flores-Benitez, David Lattner, Johanna Luschnig, Stefan Brankatschk, Marko Small GTPases Mini-Review - Commissioned The organization of intracellular transport processes is adapted specifically to different cell types, developmental stages, and physiologic requirements. Some protein traffic routes are universal to all cells and constitutively active, while other routes are cell-type specific, transient, and induced under particular conditions only. Small GTPases of the Rab (Ras related in brain) subfamily are conserved across eukaryotes and regulate most intracellular transit pathways. The complete sets of Rab proteins have been identified in model organisms, and molecular principles underlying Rab functions have been uncovered. Rabs provide intracellular landmarks that define intracellular transport sequences. Nevertheless, it remains a challenge to systematically map the subcellular distribution of all Rabs and their functional interrelations. This task requires novel tools to precisely describe and manipulate the Rab machinery in vivo. Here we discuss recent findings about Rab roles during development and we consider novel approaches to investigate Rab functions in vivo. Taylor & Francis 2017-02-17 /pmc/articles/PMC6380344/ /pubmed/28118081 http://dx.doi.org/10.1080/21541248.2017.1279725 Text en © 2017 The Author(s). Published with license by Taylor & Francis. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Mini-Review - Commissioned
Caviglia, Sara
Flores-Benitez, David
Lattner, Johanna
Luschnig, Stefan
Brankatschk, Marko
Rabs on the fly: Functions of Rab GTPases during development
title Rabs on the fly: Functions of Rab GTPases during development
title_full Rabs on the fly: Functions of Rab GTPases during development
title_fullStr Rabs on the fly: Functions of Rab GTPases during development
title_full_unstemmed Rabs on the fly: Functions of Rab GTPases during development
title_short Rabs on the fly: Functions of Rab GTPases during development
title_sort rabs on the fly: functions of rab gtpases during development
topic Mini-Review - Commissioned
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380344/
https://www.ncbi.nlm.nih.gov/pubmed/28118081
http://dx.doi.org/10.1080/21541248.2017.1279725
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