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Exonuclease domain mutants of yeast DIS3 display genome instability

The exosome functions to regulate the cellular transcriptome through RNA biogenesis, surveillance, and decay. Mutations in Dis3, a catalytic subunit of the RNA exosome with separable endonuclease and exonuclease activities, are linked to multiple myeloma. Here we report that a cancer-associated DIS3...

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Detalles Bibliográficos
Autores principales:	Milbury, Karissa L., Paul, Biplab, Lari, Azra, Fowler, Claire, Montpetit, Ben, Stirling, Peter C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2019
Materias:	Short Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380420/ https://www.ncbi.nlm.nih.gov/pubmed/30724665 http://dx.doi.org/10.1080/19491034.2019.1578600

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