Co-engaging CD47 and CD19 with a bispecific antibody abrogates B-cell receptor/CD19 association leading to impaired B-cell proliferation

CD19 is a B cell-specific receptor that regulates the threshold of B cell receptor (BCR)-mediated cell proliferation. A CD47xCD19 bispecific antibody (biAb) was generated to target and deplete B cells via multiple antibody-mediated mechanisms. Interestingly, the biAb, constructed of a CD19 binding a...

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Detalles Bibliográficos
Autores principales: Hatterer, Eric, Barba, Leticia, Noraz, Nelly, Daubeuf, Bruno, Aubry-Lachainaye, Jean-Pierre, von der Weid, Benoit, Richard, Françoise, Kosco-Vilbois, Marie, Ferlin, Walter, Shang, Limin, Buatois, Vanessa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380423/
https://www.ncbi.nlm.nih.gov/pubmed/30569825
http://dx.doi.org/10.1080/19420862.2018.1558698

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380423/
https://www.ncbi.nlm.nih.gov/pubmed/30569825
http://dx.doi.org/10.1080/19420862.2018.1558698

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