Single cell-produced and in vitro-assembled anti-FcRH5/CD3 T-cell dependent bispecific antibodies have similar in vitro and in vivo properties

Bispecific antibody production using single host cells has been a new advancement in the antibody engineering field. We previously showed comparable in vitro biological activity and in vivo mouse pharmacokinetics (PK) for two novel single cell variants (v10 and v11) and one traditional dual cell in...

Descripción completa

Detalles Bibliográficos
Autores principales: Ovacik, Ayse Meric, Li, Ji, Lemper, Marie, Danilenko, Dimitry, Stagg, Nicola, Mathieu, Mary, Ellerman, Diego, Gupta, Vinita, Kalia, Navdeep, Nguy, Trung, Plaks, Vicki, David Johnson, Clarissa, Wang, Weiru, Brumm, Jochen, Fine, Bernard, Junttila, Teemu, Lin, Kedan, Carter, Paul J., Prabhu, Saileta, Spiess, Christoph, Kamath, Amrita V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380433/
https://www.ncbi.nlm.nih.gov/pubmed/30550367
http://dx.doi.org/10.1080/19420862.2018.1551676

Ejemplares similares

Ejemplares similares